Implications of p75NTR for dentate gyrus morphology and hippocampus-related behavior revisited

详细信息    查看全文

• 作者：M. Dokter ; R. Busch ; R. Poser ; M. A. Vogt…
• 关键词：Neurotrophin ; p75NTR ; Adult neurogenesis ; Dendritic spine ; Morris water maze ; Aging
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：220
• 期：3
• 页码：1449-1462
• 全文大小：2,940 KB
• 参考文献：Barrett GL, Greferath U, Barker PA, Trieu J, Bennie A (2005) Co-expression of the P75 neurotrophin receptor and neurotrophin receptor-interacting melanoma antigen homolog in the mature rat brain. Neuroscience 133(2):381-92. doi:10.-016/?j.?neuroscience.-005.-1.-67 View Article PubMed
  Barrett GL, Reid CA, Tsafoulis C, Zhu W, Williams DA, Paolini AG, Trieu J, Murphy M (2010) Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice. Hippocampus 20(1):145-52. doi:10.-002/?hipo.-0598 PubMed
  Baryshnikova LM, von Bohlen und Halbach O, Kaplan S, von Bartheld CS (2006) Two distinct events, section compression and loss of particles (“lost caps-, contribute to z-axis distortion and bias in optical disector counting. Microsc Res Tech 69(9):738-56. doi:10.-002/?jemt.-0345 View Article PubMed
  Bernabeu RO, Longo FM (2010) The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis. BMC Neurosci 11:136. doi:10.-186/-471-2202-11-136 View Article PubMed Central PubMed
  Catts VS, Al-Menhali N, Burne TH, Colditz MJ, Coulson EJ (2008) The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours. Eur J Neurosci 28(5):883-92. doi:10.-111/?j.-460-9568.-008.-6390.?x View Article PubMed
  Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4(4):299-09. doi:10.-038/?nrn1078 View Article PubMed
  Chapleau CA, Pozzo-Miller L (2012) Divergent roles of p75(NTR) and Trk receptors in BDNF’s effects on dendritic spine density and morphology. Neural Plast 2012:578057. doi:10.-155/-012/-78057 PubMed Central PubMed
  Charalampopoulos I, Vicario A, Pediaditakis I, Gravanis A, Simi A, Ibanez CF (2012) Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor. Cell Rep 2(6):1563-570. doi:10.-016/?j.?celrep.-012.-1.-09 View Article PubMed
  Chourbaji S, Hellweg R, Brandis D, Zorner B, Zacher C, Lang UE, Henn FA, Hortnagl H, Gass P (2004) Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain Res Mol Brain Res 121(1-):28-6. doi:10.-016/?j.?molbrainres.-003.-1.-02 View Article PubMed
  Chourbaji S, Brandwein C, Vogt MA, Dormann C, Hellweg R, Gass P (2008) Nature vs. nurture: can enrichment rescue the behavioural phenotype of BDNF heterozygous mice? Behav Brain Res 192(2):254-58. doi:10.-016/?j.?bbr.-008.-4.-15 View Article PubMed
  Colditz MJ, Catts VS, Al-menhali N, Osborne GW, Bartlett PF, Coulson EJ (2010) p75 Neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis. Exp Brain Res 200(2):161-67. doi:10.-007/?s00221-009-1947-6 View Article PubMed
  Dokter M, von Bohlen und Halbach O (2012) Neurogenesis within the adult hippocampus under physiological conditions and in depression. Neural Regen Res 7(7):8. doi:10.-969/?j
  Dong Z, Bai Y, Wu X, Li H, Gong B, Howland JG, Huang Y, He W, Li T, Wang YT (2013) Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze. Neuropharmacology 64:65-3. doi:10.-016/?j.?neuropharm.-012.-6.-27 View Article PubMed
  Ehninger D, Kempermann G (2008) Neurogenesis in the adult hippocampus. Cell Tissue Res 331(1):243-50. doi:10.-007/?s00441-007-0478-3 View Article PubMed
  Freund M, Walther T, von Bohlen Und Halbach O (2013) Effects of the angiotensin-(1-7) receptor Mas on cell proliferation and on the population of doublecortin positive cells within the dentate gyrus and the piriform cortex. Eur Neuropsychopharmacol. doi:10.-016/?j.?euroneuro.-013.-6.-04 PubMed
  Friedman WJ (2000) Neurotrophins induce death of hippocampal neurons via the p75 receptor. J Neurosci 20(17):6340-346PubMed
  Frielingsdorf H, Simpson DR, Thal LJ, Pizzo DP (2007) Nerve growth factor promotes survival of new neurons in the adult hippocampus. Neurobiol Dis 26(1):47-5. doi:10.-016/?j.?nbd.-006.-1.-15 View Article PubMed
  Fujii T, Kunugi H (2009) p75NTR as a therapeutic target for neuropsychiatric diseases. Curr Mol Pharmacol 2:70-6View Article PubMed
  Gascon E, Vutskits L, Jenny B, Durbec P, Kiss JZ (2007) PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival. Development 134(6):1181-190. doi:10.-242/?dev.-2808 View Article PubMed
  Ge Y, Dong Z, Bagot RC, Howland JG, Phillips AG, Wong TP, Wang YT (2010) Hippocampal long-term depression is required for the consolidation of spatial memory. Proc Natl Acad Sci USA 107(38):16697-6702. doi:10.-073/?pnas.-008200107 View Article PubMed Central PubMed
  Giuliani A, D’Intino G, Paradisi M, Giardino L, Calza L (2004) p75(NTR)-immunoreactivity in the subventricular zone of adult
• 作者单位：M. Dokter (1)
  R. Busch (1)
  R. Poser (1)
  M. A. Vogt (2)
  V. von Bohlen und Halbach (1)
  P. Gass (2)
  K. Unsicker (3)
  O. von Bohlen und Halbach (1)
  
  1. Institute of Anatomy and Cell Biology, Universit?tsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany
  2. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany
  3. Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr.17, 79104, Freiburg, Germany
  
• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

The pan-neurotrophin receptor p75NTR is expressed in the adult brain in a discrete pattern. Although numerous studies have addressed its implications for hippocampal functions, the generated sets of data are surprisingly conflicting. We have therefore set out to re-investigate the impact of a deletion of the full-length p75NTR receptor on several parameters of the dentate gyrus (DG), including neurogenesis and hippocampus-related behavior by using p75NTRExIII knockout mice. Moreover, we investigated further parameters of the DG (cholinergic innervation, dendritic spines). In addition, we analyzed on the morphological level the impact of aging by comparing adult and aged p75NTRExIII mice and their age-matched littermates. Adult (4-?months old), but not aged (20?months old), p75NTRExIII knockout mice display an enhanced volume of the DG. However, adult neurogenesis within the adult DG was unaffected in both adult and aged p75NTRExIII knockout mice. We could further demonstrate that the change in the volume of the DG was accompanied by an increased cholinergic innervation and increased spine densities of granule cells in adult, but not aged p75NTR deficient mice. These morphological changes in the adult p75NTR deficient mice were accompanied by specific alterations in their behavior, including altered behavior in the Morris water maze test, indicating impairments in spatial memory retention.