Resource use by patients hospitalized with community-acquired pneumonia in Europe: analysis of the REACH study

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• 作者：Helmut Ostermann (1)
  Javier Garau (2)
  Jesús Medina (3)
  Esther Pascual (4)
  Kyle McBride (5)
  Francesco Blasi (6)
  
• 关键词：Anti ; bacterial agents ; Community ; acquired pneumonia ; Economics ; Medical ; Retrospective studies
• 刊名：BMC Pulmonary Medicine
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：228 KB
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  14. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2466/14/36/prepub
  
• 作者单位：Helmut Ostermann (1)
  Javier Garau (2)
  Jesús Medina (3)
  Esther Pascual (4)
  Kyle McBride (5)
  Francesco Blasi (6)
  
  1. Department of Internal Medicine III, Haematology and Oncology, University Hospital Munich, Munich, Germany
  2. Department of Medicine, Hospital Universitari Mutua de Terrassa, Plaza Doctor Robert 5, 08221, Terrassa, Barcelona, Spain
  3. Medical Evidence Centre, Global Medical Affairs, AstraZeneca, Parque Norte, Edificio Roble, Serrano Galvache 56, 28033, Madrid, Spain
  4. Medical Department, Clinical Research Unit, AstraZeneca, Parque Norte, Edificio Roble, Serrano Galvache 56, 28033, Madrid, Spain
  5. Instat Services, Inc., 1 Wilson Street, Chatham, NJ, 07928, USA
  6. Department of Pathophysiology and Transplantation, Università degli Studi di Milano, IRCCS Fondazione Ca-Granda, Ospedale Maggiore Policlinico, Milan, Italy
  
• ISSN：1471-2466

文摘

Background Management of community-acquired pneumonia (CAP) places a considerable burden on hospital resources. REACH was a retrospective, observational study (NCT01293435) involving adults ?8?years old hospitalized with CAP and requiring in-hospital treatment with intravenous antibiotics conducted to collect data on current clinical management patterns and resource use for CAP in hospitals in ten European countries. Methods Data were collected via electronic Case Report Forms detailing patient and disease characteristics, microbiological diagnosis, treatments before and during hospitalization, clinical outcomes and health resource consumption. Results Patients with initial antibiotic treatment modification (n--89; 28.9%) had a longer mean hospital stay than those without (16.1 [SD: 13.1; median 12.0] versus 11.1 [SD: 8.9; median: 9.0] days) and higher ICU admission rate (18.0% versus 11.9%). Septic shock (6.8% versus 3.0%), mechanical ventilation (22.2% versus 9.7%), blood pressure support (fluid resuscitation: 19.4% versus 11.4%), parenteral nutrition (6.5% versus 3.9%) and renal replacement therapy (4.2% versus 1.4%) were all more common in patients with treatment modification than in those without. Hospital stay was longer in patients with comorbidities than in those without (mean 13.3 [SD: 11.1; median: 10.0] versus 10.0 [SD: 7.5; median: 8.0] days). Conclusions Initial antibiotic treatment modification in patients with CAP is common and is associated with considerable additional resource use. Reassessment of optimal management paradigms for patients hospitalized with CAP may be warranted.