Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

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• 作者：Federica Filice ; Karl Jakob Vörckel ; Ayse Özge Sungur ; Markus Wöhr…
• 关键词：Parvalbumin ; Shank1 ; Shank3 ; Autism ; Perineuronal net ; Calcium ; binding protein ; Calcium homeostasis
• 刊名：Molecular Brain
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：1
• 全文大小：2,959 KB
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• 作者单位：Federica Filice (1)
  Karl Jakob Vörckel (2)
  Ayse Özge Sungur (2)
  Markus Wöhr (2)
  Beat Schwaller (1)
  
  1. Anatomy, Department of Medicine, University of Fribourg, Route Albert-Gockel 1, CH-1700, Fribourg, Switzerland
  2. Behavioral Neuroscience, Faculty of Psychology, Philipps-University of Marburg, Gutenbergstraβe 18, D-35032, Marburg, Germany
  
• 刊物主题：Neurosciences; Neurology;
• 出版者：BioMed Central
• ISSN：1756-6606

文摘

Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV+) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK being one of the most important gene families mutated in human ASD. Similar findings were obtained in heterozygous (PV+/-) mice for the Pvalb gene, which display a robust ASD-like phenotype. Here, we addressed the question whether the observed reduction in PV immunoreactivity was the result of a decrease in PV expression levels and/or loss of the PV-expressing GABA interneuron subpopulation hereafter called “Pvalb neurons”. The two alternatives have important implications as they likely result in opposing effects on the excitation/inhibition balance, with decreased PV expression resulting in enhanced inhibition, but loss of the Pvalb neuron subpopulation in reduced inhibition.