Synthesis of Composites SBA-15 Mesoporous Particles Carrying Oxytocin and Evaluation of Their Properties, Functions, and In Vitro Biological Activities

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• 作者：Ming Qian (1)
  Min Liu (2)
  Mengna Duan (1)
  Zhe Wu (1)
  Yanmin Zhou (3)
  
  1. Department of Prosthodontics ; School of Stomatology ; Jilin University ; Changchun ; 130021 ; Jilin ; China
  2. Department of Periodontics ; School of Stomatology ; Jilin University ; Changchun ; 130021 ; Jilin ; China
  3. Department of Implantology ; School of Stomatology ; Jilin University ; Changchun ; 130021 ; Jilin ; China
  
• 关键词：Mesoporous particles ; SBA ; 15 ; Oxytocin ; Bone defect
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：71
• 期：1
• 页码：127-134
• 全文大小：1,113 KB
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• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

Using the organic template method, we have synthesized mesoporous SBA-15 particles and characterized them by scanning electron microscopy and transmission electron microscopy. The bone metabolism regulating hormone oxytocin (OT) was selected as a model for preparation of drug/SBA-15 complexes. The process of drug loading was studied using X-ray diffraction and nitrogen absorption methods. Optimal drug loading parameters were experimentally investigated. The kinetics of drug release from the carrier was evaluated. Finally, the extractions of SBA-15 particles were tested for cytotoxicity, in vitro hemolysis, and the direct attachment toxicity. Our findings suggest that SBA-15 materials have good biocompatibility. Moreover, we demonstrated that OT/SBA-15 complex can stimulate alkaline phosphatase activity in osteoblast cells. The study provides fundamental information for further in vivo drug-carrier testing.