Bacterial Virulence Factors: Secreted for Survival

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• 作者：Aditya Kumar Sharma ; Neha Dhasmana ; Neha Dubey…
• 关键词：Mycobacterium ; Virulence ; Bacillus ; Anthrax ; Tuberculosis ; Phosphatases
• 刊名：Indian Journal of Microbiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：57
• 期：1
• 页码：1-10
• 全文大小：
• 刊物主题：Microbiology; Medical Microbiology;
• 出版者：Springer India
• ISSN：0973-7715
• 卷排序：57

文摘

Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive—metabolic, physiological and morphological shifts. The membrane associated virulence factors aid the bacterium in adhesion and evasion of the host cell. The secretory factors are important components of bacterial armoury which help the bacterium wade through the innate and adaptive immune response mounted within the host. In extracellular pathogens, the secretory virulence factors act synergistically to kill the host cells. In this review, we revisit the role of some of the secreted virulence factors of two human pathogens: Mycobacterium tuberculosis—an intracellular pathogen and Bacillus anthracis—an extracellular pathogen. The advances in research on the role of secretory factors of these pathogens during infection are discussed.