Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation
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- 作者：Xiaoyun Tang ; Xianyan Wang ; Yuan Y. Zhao ; Jonathan M. Curtis…
- 关键词：Autotaxin ; Inflammatory cyotokines ; Tetracyclines ; Peripheral blood mononuclear cells ; Macrophage infiltration
- 刊名：Molecular Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1993KB
- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1476-4598
- 卷排序：16
文摘
BackgroundWe previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increases the turnover of plasma lysophosphatidate and decreases its concentration. Extracellular lysophosphatidate signals through six G protein-coupled receptors and it is a potent promoter of tumor growth, metastasis and chemo-resistance. These effects depend partly on the stimulation of inflammation that lysophosphatidate produces.