Distribution of mast cells in benign odontogenic tumors

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• 作者：Francisco de Assis Caldas Pereira (1)
  Clarissa Araújo Silva Gurgel (1)
  Eduardo Ant?nio Gon?alves Ramos (2)
  Manuela Torres Andion Vidal (1)
  Ant?nio Luiz Barbosa Pinheiro (3)
  Vladimir Jurisic (4)
  Caroline Brandi Schlaepfer Sales (2)
  Patrícia Ramos Cury (5)
  Jean Nunes dos Santos (1) (6)
  
• 关键词：Mast cell ; Immunohistochemistry ; Odontogenic tumors ; Ameloblastomas
• 刊名：Tumor Biology
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：33
• 期：2
• 页码：455-461
• 全文大小：486KB
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• 作者单位：Francisco de Assis Caldas Pereira (1)
  Clarissa Araújo Silva Gurgel (1)
  Eduardo Ant?nio Gon?alves Ramos (2)
  Manuela Torres Andion Vidal (1)
  Ant?nio Luiz Barbosa Pinheiro (3)
  Vladimir Jurisic (4)
  Caroline Brandi Schlaepfer Sales (2)
  Patrícia Ramos Cury (5)
  Jean Nunes dos Santos (1) (6)
  
  1. Department of Oral Pathology, Laboratory of Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil
  2. Gon?alo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil
  3. Center of Biophotonic, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil
  4. School of Medicine, University of Kragujevac, Belgrade, Serbia
  5. Department of Periodontics, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil
  6. Faculdade de odontologia, Laboratório de Patologia Cirúrgica, Universidade Federal da Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia, 40110-150, Brazil
  
• ISSN：1423-0380

文摘

The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands, with or without squamous metaplasia. The odontogenic mixoma showed few mast cells. In odontogenic tumors with a cystic structure, the mast cells were distributed throughout all areas of the lesions, mainly in keratocystic odontogenic tumor. In addition, the total density of mast cells between all odontogenic tumors showed no significant difference (p-gt;-.05). A greater mast cells distribution was found in keratocystic odontogenic tumor in relation to adenomatoid odontogenic tumor (p-lt;-.01), and when the unicystic ameloblastoma and keratocistic odontogenic tumor were compared to the odontogenic myxoma (p-lt;-.05). Syndrome keratocystic odontogenic tumor showed a higher mean of mast cells when compared with the other tumors of the sample. Mast cells values presented by syndrome keratocystic odontogenic tumor were significantly greater than those of the sporadic keratocystic odontogenic tumor that were not associated with the syndrome (p--.03). Mast cells are probably one of the major components of the stromal scaffold in odontogenic tumors. We found significant differences of mast cells between syndrome nonsyndrome keratocystic odontogenic tumors, although their distribution did not seem to have any influence on the biologic behavior of benign odontogenic tumors.