Occult HBV infection in the oncohematological setting

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• 作者：C. Sagnelli ; M. Macera ; M. Pisaturo ; R. Zampino ; M. Coppola ; E. Sagnelli
• 关键词：Occult HBV infection ; Silent HBV infection ; Oncohematological setting ; Immunosuppression ; HBV prophylactic measures ; HBV infection
• 刊名：Infection
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：44
• 期：5
• 页码：575-582
• 全文大小：586 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Infectious Diseases
  General Practice and Family Medicine
  Internal Medicine
  
• 出版者：Urban & Vogel
• ISSN：1439-0973
• 卷排序：44

文摘

IntroductionOccult hepatitis B infection (OBI), a virological condition characterized by a low release of Hepatitis B Virus (HBV) from liver cells and low HBV-DNA levels in serum and/or liver tissue of HBsAg-negative subjects, may reactivate in oncohematological patients undergoing immunosuppression by aggressive chemotherapy or hematopoietic stem cell transplantation. The entity of OBI reactivation varies from an increase in HBV replication without liver damage to an active HBV replication followed by liver cell necrosis, frequently severe and in some cases life threatening. Because of a possible severe outcome associated with OBI reactivation (hepatic failure or death due to the discontinuation of chemotherapy), prophylaxis with anti-HBV nucleot(s)ide analogues is recommended in relation to the foreseeable degree of immunosuppression.