Modulation of factors involved in placental haemostasis and angiogenesis by low-molecular-weight-heparins

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• 作者：Elvira Grandone ; Elena Chinni ; Michela Villani…
• 关键词：Tissue ; factor ; Vascular endothelial growth factor ; Low ; molecular ; weight ; heparins ; Gestational vascular complications
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：294
• 期：6
• 页码：1323-1329
• 全文大小：677 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711
• 卷排序：294

文摘

PurposeIn placentae from uneventful pregnancies a direct relationship between expression of tissue factor (TF) and tissue-factor pathway inhibitor type 2 (TFPI2) was found, as well as between TF and vascular endothelial growth factor (VEGF). Furthermore, placentae from gestational vascular complications (GVCs) lack these correlations. Aims of the present study are (1) to evaluate a possible role of low-molecular-weight-heparins (LMWHs) in the modulation of the expression of TF, TFPI, TFPI2 and VEGF in placentae from thrombophilic women and (2) to study the possible role of endothelium in the placental expression of markers involved in haemostasis and angiogenesis.