One-step synthesis of pyrido[2,3-d]pyrimidines, amides, and benzoxazolylethylpyrimidine by condensation of substituted 3-(2-phenylpyrimidin-5-yl)propanoic acids with aromatic amines in polyphosphoric acid

详细信息    查看全文

• 作者：A. A. Harutyunyan ; H. A. Panosyan…
• 刊名：Russian Journal of Organic Chemistry
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：51
• 期：3
• 页码：357-360
• 全文大小：276 KB
• 参考文献：1.Harutyunyan, A.A., Khim. Zh. Arm., 2012, vol. 65, p. 257.
  2.Harutyunyan, A.A., Russ. J. Org. Chem., 2014, vol. 50, p. 94.View Article
  3.Harutyunyan, A.A., Panosyan, H.A., Tamazyan, R.A., and Ayvazyan, A.G., Khim. Zh. Arm., 2014, vol. 67, p. 214.
  4.Palatinus, L. and Chapuis, G., J. Appl. Crystallogr., 2007, vol. 40, p. 786.View Article
  5.Petricek, V., Dusek, M., and Palatinus, L., JANA. Structure Determination Software Programs, Praha, Czech Republic: Institute of Physics, 2006.
  6.Hullar, T.L. and French, W.C., J. Med. Chem., 1969, vol. 12, p. 424.View Article
  
• 作者单位：A. A. Harutyunyan (1)
  H. A. Panosyan (2)
  S. G. Chishmarityan (2)
  R. A. Tamazyan (2)
  A. G. Ayvazyan (2)
  
  1. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, pr. Azatutyan 26, Yerevan, 0014, Armenia
  2. Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, pr. Azatutyan 26, Yerevan, 0014, Armenia
  
• 刊物主题：Organic Chemistry;
• 出版者：Springer US
• ISSN：1608-3393

文摘

Depending on the reactant structure, reactions of substituted 3-(2-phenylpyrimidin-5-yl)propanoic acids with 2-aminopyridine, p-toluidine, and 2-aminophenol in polyphosphoric acid afforded the corresponding N-(pyridin-2-yl)propanamides, 5-[2-(benzoxazol-2-yl)ethyl]pyrimidine, and pyrido[2,3-d]pyrimidinones.