T_H9 cells in skin disorders

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• 作者：Rachael A. Clark ; Christoph Schlapbach
• 关键词：Interleukin 9 ; IL ; 9 ; T helper cells ; T helper cell subsets ; T helper type 9 cells ; Th9 cells ; Skin ; Cutaneous ; Inflammation ; Skin resident ; Skin homing ; Atopic dermatitis ; Candida albicans ; Allergic contact dermatitis ; Psoriasis ; Cutaneous T cell lymphoma
• 刊名：Seminars in Immunopathology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：1
• 页码：47-54
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Internal Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2300
• 卷排序：39

文摘

Interleukin 9 secreting T_H9 cells have been proposed as the latest addition to the family of T helper cell subsets. While a growing body of evidence from animal models points to important roles for these cells in allergic inflammation of the lung, autoinflammation of the gastrointestinal tract, and tumor immunity, their role in skin immunity and skin immunopathology remains poorly defined. Interestingly, studies of T helper cells from healthy humans suggest that T_H9 cells are predominantly skin-homing and skin-resident and that they are involved in protection against extracellular pathogens. Thus, T_H9 cells have entered the stage as potential mediators of cutaneous pathology. However, under which conditions and by which mechanisms these cells contribute to skin immunity and disease still has to be investigated. Here, we review our current understanding of T_H9 cells as skin-tropic T helper cells and their involvement in skin pathology. Further, we discuss open questions with regard to the intricate nature of interleukin 9 producing T helper cells.