Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

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• 作者：Victoria Sandler ; Anna C. Reisetter ; James R. Bain ; Michael J. Muehlbauer…
• 关键词：Fetal growth ; Maternal BMI ; Maternal insulin resistance ; Maternal metabolism ; Pregnancy
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：60
• 期：3
• 页码：518-530
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisMaternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediated through the intrauterine environment. We aimed to characterise the maternal metabolic milieu associated with maternal BMI and its relationship to newborn birthweight and adiposity.