Effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis

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• 作者：Rebecca E Giglio ; Guohua Li ; Charles J DiMaggio
• 关键词：Opioid overdose ; Naloxone ; Overdose prevention ; Bystander
• 刊名：Injury Epidemiology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：2
• 期：1
• 全文大小：637KB
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  Strang J, Manning V, May
• 作者单位：Rebecca E Giglio (1)
  Guohua Li (1) (2) (3)
  Charles J DiMaggio (2) (4)
  
  1. Center for Injury Epidemiology and Prevention, Columbia University, 722 West 168th St, 5th Floor, New York, 10032, NY, USA
  2. Department of Epidemiology, Columbia University Mailman School of Public Health, 722 West 168th St, New York, 10032, NY, USA
  3. Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th St, PH5-505, New York, 10032, NY, USA
  4. Department of Surgery, New York University School of Medicine, 550, First Avenue, New York, NY, 10016, USA
  
• 刊物类别：Statistics for Life Sciences, Medicine, Health Sciences; Epidemiology; Biostatistics; Public Health;
• 刊物主题：Statistics for Life Sciences, Medicine, Health Sciences; Epidemiology; Biostatistics; Public Health; Statistical Theory and Methods;
• 出版者：Springer International Publishing
• ISSN：2197-1714

文摘

The objective of this review was to assess the effectiveness of bystander naloxone administration and overdose education programs by synthesizing quantitative results reported in the research literature. Studies meeting predefined criteria were identified and reviewed, and their results were synthesized through meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for overdose recoveries for individuals who received naloxone dispensed by non-medical community members, and the standardized mean difference was calculated for test scores of non-medical volunteers who received training in overdose management versus the scores of untrained volunteers. Pooled data from four studies showed that naloxone administration by bystanders was associated with a significantly increased odds of recovery compared with no naloxone administration (OR--.58, 95% CI--.90 to 13.25). Data from five studies of overdose education indicated that average scores were significantly higher for trained participants than untrained participants for tests on naloxone administration, overdose recognition, and overdose response (standardized mean difference--.35, 95% CI--.92 to 1.77). Empirical evidence in the research literature suggests that bystander naloxone administration and overdose education programs are associated with increased odds of recovery and with improved knowledge of overdose recognition and management in non-clinical settings. Keywords Opioid overdose Naloxone Overdose prevention Bystander