Gender aspects in clinical presentation and prognostication of chronic heart failure according to NT-proBNP and the Heart Failure Survival Score

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• 作者：Jennifer Franke ; Andreas Lindmark ; Matthias Hochadel…
• 关键词：Chronic heart failure ; Gender ; Risk score ; Heart Failure Survival Score ; NT ; proBNP
• 刊名：Clinical Research in Cardiology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：104
• 期：4
• 页码：334-341
• 全文大小：270 KB
• 参考文献：1. Regitz-Zagrosek, V, Oertelt-Prigione, S, Seeland, U, Hetzer, R (2010) Sex and gender differences in myocardial hypertrophy and heart failure. Circ J: Off J Jpn Circ Soc 74: pp. 1265-1273 CrossRef
  2. Hussey, LC, Hardin, S (2003) Sex-related differences in heart failure. Heart Lung: J Crit Care 32: pp. 215-223 CrossRef
  3. Levy, D, Larson, MG, Vasan, RS, Kannel, WB, Ho, KK (1996) The progression from hypertension to congestive heart failure. JAMA, J Am Med Assoc 275: pp. 1557-1562 CrossRef
  4. Frankenstein, L, Clark, AL, Ribeiro, JP (2012) Influence of sex on treatment and outcome in chronic heart failure. Cardiovasc Ther 30: pp. 182-192 CrossRef
  5. Elliott, P, Andersson, B, Arbustini, E, Bilinska, Z, Cecchi, F, Charron, P, Dubourg, O, Kuhl, U, Maisch, B, McKenna, WJ, Monserrat, L, Pankuweit, S, Rapezzi, C, Seferovic, P, Tavazzi, L, Keren, A (2008) Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 29: pp. 270-276 CrossRef
  6. Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, Moss AJ, Seidman CE, Young JB, American Heart A, Council on Clinical Cardiology HF, Transplantation C, Quality of C, Outcomes R, Functional G, Translational Biology Interdisciplinary Working G, Council on E, Prevention (2006) Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 113(14):1807-816. doi:10.1161/CIRCULATIONAHA.106.174287
  7. Lang, RM, Bierig, M, Devereux, RB, Flachskampf, FA, Foster, E, Pellikka, PA, Picard, MH, Roman, MJ, Seward, J, Shanewise, JS, Solomon, SD, Spencer, KT, Sutton, MS, Stewart, WJ (2005) Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr: Off Publ Am Soc Echocardiogr 18: pp. 1440-1463 CrossRef
  8. Lang, RM, Bierig, M, Devereux, RB, Flachskampf, FA, Foster, E, Pellikka, PA, Picard, MH, Roman, MJ, Seward, J, Shanewise, J, Solomon, S, Spencer, KT, St John Sutton, M, Stewart, W (2006) Recommendations for chamber quantification. Eur J Echocardiogr: J Work Group Echocardiogr Eur Soc Cardiol 7: pp. 79-108 CrossRef
  9. DeLong, ER, DeLong, DM, Clarke-Pearson, DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44: pp. 837-845 CrossRef
  10. Aaronson, KD, Schwartz, JS, Chen, TM, Wong, KL, Goin, JE, Mancini, DM (1997) Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation 95: pp. 2660-2667 CrossRef
  11. Mehra, MR, Kobashigawa, J, Starling, R, Russell, S, Uber, PA, Parameshwar, J, Mohacsi, P, Augustine, S, Aaronson, K, Barr, M (2006) Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates-006. J Heart Lung Transplant:Off Publ Int Soc Heart Transplant 25: pp. 1024-1042 CrossRef
  12. Goda, A, Williams, P, Mancini, D, Lund, LH (2011) Selecting patients for heart transplantation: comparison of the Heart Failure Surviva
• 刊物主题：Cardiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1861-0692

文摘

Aims We performed a prospective multi-center study to assess gender-specific differences in the predictive value of the measured level of NT-proBNP and the calculated Heart Failure Survival Score (HFSS). Methods Baseline characteristics and follow-up data up to 5?years from 2,019 men and 530 women diagnosed with chronic heart failure (CHF) due to ischemic heart disease or dilated cardiomyopathy were prospectively compared. Death from any cause constituted the endpoint of the study. NT-proBNP was measured and HFSS calculated according to standard methods. Survival of men and women according to level of NT-proBNP and HFSS was analyzed in logistic regression models. Results Median NT-proBNP level in men was 1,394?ng/l (IQR 516-,406?ng/l) and 1,168?ng/l (IQR 444-,830?ng/l) in women (p?=?n.s.). Median HFSS value was 8.4 (IQR 7.7-.1) and 8.5 (8.0-.1) in men and women, respectively. NT-proBNP levels and HFSS score correlated well with survival rates in both genders (p for interaction?=?0.22 for NT-proBNP and 0.93 for HFSS). The all-cause death rates were similar in men and women. Conclusion Despite a number of gender-specific differences in CHF and the general predominance of men measured levels of NT-proBNP and HFSS score can be utilized for risk stratification with similar informative value in men and women.