Procalcitonin-guided antibiotic treatment in critically ill patients

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• 作者：Andreas Hohn ; Bernhard Heising ; Jan-Karl Schütte…
• 关键词：Procalcitonin ; Sepsis ; Antibiotic treatment ; Antibiotic stewardship
• 刊名：Langenbeck's Archives of Surgery
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：402
• 期：1
• 页码：1-13
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：General Surgery; Abdominal Surgery; Cardiac Surgery; Thoracic Surgery; Traumatic Surgery; Vascular Surgery;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-2451
• 卷排序：402

文摘

PurposeIn critically ill patients, length of antibiotic treatment can be effectively guided by procalcitonin (PCT) protocols. International sepsis guidelines and guidelines on antibiotic stewardship strategies recommend PCT as helpful laboratory marker for a rational use of antibiotics. A number of studies and meta-analyses have confirmed the effectiveness of PCT-protocols for shortening antibiotic treatment without compromising clinical outcome in critically ill patients. But in clinical practice, there is still uncertainty how to interpret PCT levels and how to adjust antibiotic treatment in various infectious situations, especially in the perioperative period.