Topography and collateralization of dopaminergic projections to primary motor cortex in rats

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• 作者：Jonas A. Hosp (1) (2)
  Helen E. Nolan (1) (2)
  Andreas R. Luft (1) (2) (3)
  
  1. Clinical Neurorehabilitation ; Department of Neurology ; University of Zurich ; Frauenklinikstrasse 26 ; 8091 ; Zurich ; Switzerland
  2. Rehabilitation Initiative and Technology Center Zurich ; RITZ ; Zurich ; Switzerland
  3. Department of Neurology ; Johns Hopkins University ; 1550 Orleans Street ; Baltimore ; MD ; 21231 ; USA
  
• 关键词：Motor cortex ; Dopamine ; VTA ; Rat
• 刊名：Experimental Brain Research
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：233
• 期：5
• 页码：1365-1375
• 全文大小：1,376 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1106

文摘

Dopaminergic signaling within the primary motor cortex (M1) is necessary for successful motor skill learning. Dopaminergic neurons projecting to M1 are located in the ventral tegmental area (VTA, nucleus A10) of the midbrain. It is unknown which behavioral correlates are encoded by these neurons. The objective here is to investigate whether VTA-M1 fibers are collaterals of projections to prefrontal cortex (PFC) or nucleus accumbens (NAc) or if they form a distinct pathway. In rats, multiple-site retrograde fluorescent tracers were injected into M1, PFC and the core region of the NAc and VTA sections investigated for concomitant labeling of different tracers. Dopaminergic neurons projecting to M1, PFC and NAc were found in nucleus A10 and to a lesser degree in the medial nucleus A9. Neurons show high target specificity, minimal collateral branching to other than their target area and hardly cross the midline. Whereas PFC- and NAc-projecting neurons are indistinguishably intermingled within the ventral portion of dopaminergic nuclei in middle and caudal midbrain, M1-projecting neurons are only located within the dorsal part of the rostral midbrain. Within M1, the forelimb representation receives sevenfold more dopaminergic projections than the hindlimb representation. This strong rostro-caudal gradient as well as the topographical preference to dorsal structures suggest that projections to M1 emerged late in the development of the dopaminergic systems in and form a functionally distinct system.