Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk
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- 作者：Antonino De Lorenzo ; Sergio Bernardini ; Paola Gualtieri…
- 关键词：Oxidized ; LDL ; Nutrigenomic ; Mediterranean meal ; CVD
- 刊名：Acta Diabetologica
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：54
- 期：2
- 页码：141-149
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Internal Medicine; Diabetes; Metabolic Diseases;
- 出版者：Springer Milan
- ISSN：1432-5233
- 卷排序：54
文摘
AimsInflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Micronutrients modulate immune system and exert a protective action by reducing oxidized low-density lipoprotein (ox-LDL) level. The aim of the present study was to evaluate the postprandial plasma ox-LDL level and the gene expression of 13 genes related to oxidative stress (HOSp) and human inflammasome pathways (HIp), after a tocopherol-enriched Mediterranean meal (TEM), and a Western high-fat meal (HFM). Moreover, Mediterranean Adequacy Index was calculated to define the quality of both meals.