Epigenetic Downregulation of PTEN in Gallbladder Cancer
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- 作者：Dinesh Singh Tekcham ; Sanjeev Gupta…
- 关键词：Epigenetic ; Gallbladder cancer ; Gallstone diseases ; Methylation ; PTEN
- 刊名：Journal of Gastrointestinal Cancer
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：48
- 期：1
- 页码：110-116
- 全文大小：
- 刊物主题：Oncology; Gastroenterology; Radiotherapy; Cancer Research; Internal Medicine;
- 出版者：Springer US
- ISSN：1941-6636
- 卷排序：48
文摘
PurposeGallbladder cancer (GBC) is becoming a global health problem. Phosphatase and tensin homolog (PTEN), also known as guardian gene of cancer, encodes a protein, which dephosphorylates phosphatidylinositol (3,4,5) triphosphate {PtdIns (3,4,5) P3 } into phosphatidylinositol (4,5) diphosphate {PtdIns (4,5) P2} that results in the inhibition of AKT/PKB signaling pathway. PTEN plays a key role in the pathogenesis of various cancers. However, its role in GBC is still obscure. The present study was aimed to identify the epigenetic role of PTEN in GBC and GSD.