Anti-diabetic effects of polysaccharides from ethanol-insoluble residue of Schisandra chinensis (Turcz.) Baill on alloxan-induced diabetic mice

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• 作者：Ting Zhao (1)
  Guang-hua Mao (1)
  Min Zhang (2)
  Fang Li (1)
  Ye Zou (1)
  Ye Zhou (3)
  Wei Zheng (3)
  Da-heng Zheng (1)
  Liu-qing Yang (2)
  Xiang-yang Wu (4)
  
• 关键词：Schisandra chinensis (Turcz.) Baill ; Ethanol ; insoluble residue ; Polysaccharide ; Diabetes mellitus ; Hypoglycemic activity
• 刊名：Chemical Research in Chinese Universities
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：29
• 期：1
• 页码：99-102
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• 作者单位：Ting Zhao (1)
  Guang-hua Mao (1)
  Min Zhang (2)
  Fang Li (1)
  Ye Zou (1)
  Ye Zhou (3)
  Wei Zheng (3)
  Da-heng Zheng (1)
  Liu-qing Yang (2)
  Xiang-yang Wu (4)
  
  1. College of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, P. R. China
  2. College of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, P. R. China
  3. College of Pharmacy, Jiangsu University, Zhenjiang, 212013, P. R. China
  4. College of Environment, Jiangsu University, Zhenjiang, 212013, P. R. China
  
• ISSN：2210-3171

文摘

The ethanol-insoluble residue of Schisandra generated during lignans industrial production is usually treated as solid waste. However, there is active polysaccharide which could be used in it. In this work, the water-soluble polysaccharides from the ethanol-insoluble residue of Schisandra (ESCP) were obtained and their anti-diabetic effect was evaluated. The results indicate that ESCP could significantly reduce the blood glucose level in alloxan-induced diabetic mice. Moreover, the ESCP could significantly improve the lipid metabolism and increase the content of liver glycogen in alloxan-induced diabetic mice. The results indicate that ESCP could be developed into a potential natural hypoglycemic agent.