The Distribution in Tissues and Urine of Arsenic Metabolites After Subchronic Exposure to Dimethylarsinic Acid (DMAV) in Rats

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• 作者：Shengnan Liu ; Lin Zhang ; Qingshan Sun ; Fei Wang…
• 关键词：DMAV ; Rat ; Metabolism ; Distribution ; Arsenicals ; Urine ; Tissues
• 刊名：Biological Trace Element Research
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：164
• 期：2
• 页码：219-225
• 全文大小：796 KB
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• 刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
• 出版者：Springer US
• ISSN：1559-0720

文摘

Dimethylarsinic acid (DMAV) acted as cancer promoter promoted urinary bladder, liver, and lung carcinogenesis in rats. Understanding of the distribution of arsenicals in critical sites will aid to define the action of DMAV-induced toxicity and carcinogenicity. The present experiment was conducted to compare the accumulated levels of arsenicals in the liver, kidney, and bladder of both male and female rats after subchronic exposure to DMAV. After exposure to DMAV in drinking water for 10?weeks, urinary DMA concentrations of 100 and 200?ppm DMAV–treated rats increased significantly compared with those of the control rats. Smaller amount of trimethylarsinic acid (TMA) was detected in urine, but not in liver, kidney, and bladder muscle. In the liver and kidney, the levels of DMA in DMAV-treated rats significantly increased compared with those of the control group, but there was no difference between 100 and 200?ppm DMAV–treated rats. DMA did not accumulate in bladder muscle. There was no difference for DMA concentrations between male and female rats. Our results suggest that the accumulation of DMA in the liver and kidney was saturated above 100?ppm DMAV treatment concentration, and DMAV was a little partly metabolized to TMA, and TMA was rapidly excreted into urine.