MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential

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• 作者：Wei Wang ; Yun-ping Luo
• 关键词：Breast cancer ; MicroRNA ; Oncogene ; Tumor suppressors ; Diagnosis marker ; MicroRNA ; based therapy ; R737.9 ; MicroRNA ; /li> /li> ; /li>
• 刊名：Journal of Zhejiang University SCIENCE B
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：16
• 期：1
• 页码：18-31
• 全文大小：560 KB
• 参考文献：1. Ahmad, A., Aboukameel, A., Kong, D.J., / et al., 2011. Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells. / Cancer Res., 71(9):3400-409. [doi:10.1158/0008-5472.CAN-10-0965]
  2. Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., / et al., 2003. Prospective identification of tumorigenic breast cancer cells. / PNAS, 100(7):3983-988. [doi:10.1073/pnas.0530291100]
  3. Andorfer, C.A., Necela, B.M., Thompson, E.A., / et al., 2011. MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer. / Trends Mol. Med., 17(6):313-19. [doi:10.1016/j.molmed.2011.01.006]
  4. Asaga, S., Kuo, C., Nguyen, T., / et al., 2011. Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer. / Clin. Chem., 57(1):84-1. [doi:10.1373/clinchem.2010.151845]
  5. Barh, D., Malhotra, R., Ravi, B., / et al., 2010. MicroRNA let-7: an emerging next-generation cancer therapeutic. / Curr. Oncol., 17(1):70-0. [doi:10.3747/co.v17i1.356]
  6. Bartel, D.P., 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. / Cell, 116(2):281-97. [doi:10.1016/S0092-8674(04)00045-5]
  7. Bertucci, F., Finetti, P., Rougemont, J., / et al., 2005. Gene expression profiling identifies molecular subtypes of inflammatory breast cancer. / Cancer Res., 65(6): 2170-178. [doi:10.1158/0008-5472.CAN-04-4115]
  8. Bhaumik, D., Scott, G.K., Schokrpur, S., / et al., 2008. Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells. / Oncogene, 27(42):5643-647. [doi:10.1038/onc.2008.171]
  9. Blenkiron, C., Goldstein, L.D., Thorne, N.P., / et al., 2007. MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. / Genome Biol., 8(10):R214. [doi:10.1186/gb-2007-8-10-r214]
  10. Bockhorn, J., Yee, K., Chang, Y.F., / et al., 2013. MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. / Breast Cancer Res. Treat., 137(2):373-82. [doi:10.1007/s10549-012-2346-4]
  11. Brabletz, T., Jung, A., Spaderna, S., / et al., 2005. Migrating cancer stem cells—an integrated concept of malignant tumour progression. / Nat. Rev. Cancer, 5(9):744-49. [doi:10.1038/nrc1694]
  12. Brognara, E., Fabbri, E., Aimi, F., / et al., 2012. Peptide nucleic acids targeting miR-221 modulate p27Kip1 expression in breast cancer MDA-MB-231 cells. / Int. J. Mol. Med., 30:S59. [doi:10.3892/ijo.2012.1632]
  13. Buffa, F.M., Camps, C., Winchester, L., / et al., 2011. MicroRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer. / Cancer Res., 71(17): 5635-645. [doi:10.1158/0008-5472.CAN-11-0489]
  14. Cai, J.C., Guan, H.Y., Fang, L.S., / et al., 2013. MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. / J. Clin. Invest., 123(2):566-79. [doi:10.1172/Jci65871]
  15. Calin, G.A., Croce, C.M., 2006. MicroRNA signatures in human cancers. / Nat. Rev. Cancer, 6(11):857-66. [doi:10.1038/nrc1997]
  16. Cascio, S., D’Andrea, A., Ferla, R., / et al., 2010. miR-20b modulates / VEGF expression by targeting HIF-1α and STAT3 in MCF-7 breast cancer cells. / J. Cell Physiol., 224(1):242-49. [doi:10.1002/Jcp.22126]
  17. Cha, S.T., Chen, P.S., Johansson, G., / et al., 2010. MicroRNA-519c suppresses hypoxia-inducible factor-1α expression and tumor angiogenesis. / Cancer Res., 70(7):2675-685. [doi:10.1158/0008-5472.CAN-09-2448]
  18. Chan, J.A., Krichevsky, A.M., Kosik, K.S., 2005. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. / Cancer Res., 65(14):6029-033. [doi:10.1158/0008-5472.CAN-05-0137]
  19. Chao, C.H., Chang, C.C., Wu, M.J., / et al., 2014. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. / J. Clin. Invest., 124(7):3093-106. [doi:10.1172/JCI73351]
  20. Chen, W.X., Hu, Q., Qiu, M.T., / et al., 2013. miR-221/222: promising biomarkers for breast cancer. / Tumor Biol., 34(3):1361-370. [doi:10.1007/s13277-013-0750-y]
  21. Chen, X., Gao, C., Li, H.J., / et al., 2010. Identification and characteriz
• 刊物主题：Biomedicine general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1862-1783

文摘

MicroRNAs (miRs) are small single-stranded RNA molecules, which function as key negative regulators of post-transcriptional modulation in almost all biological processes. Abnormal expression of microRNAs has been observed in various types of cancer including breast cancer. Great efforts have been made to identify an association between microRNA expression profiles and breast cancer, and to understand the functional role and molecular mechanism of aberrant-expressed microRNAs. As research progressed, ‘oncogenic microRNAs-and ‘tumor suppressive microRNAs-became a focus of interest. The potential of candidate microRNAs from both intercellular (tissue) and extracellular (serum) sources for clinical diagnosis and prognosis was revealed, and treatments involving microRNA achieved some amazing curative effects in cancer disease models. In this review, advances from the most recent studies of microRNAs in one of the most common cancers, breast cancer, are highlighted, especially the functions of specifically selected microRNAs. We also assess the potential value of these microRNAs as diagnostic and prognostic markers, and discuss the possible development of microRNA-based therapies.