Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers
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- 作者：Ingrid J. G. Burvenich ; Fook-Thean Lee ; Graeme J. O'Keefe ; Dahna Makris…
- 关键词：Therapeutic ratio ; Payload delivery ; Antibody engineering ; Small animal imaging ; Lewis ; Y
- 刊名：EJNMMI Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：6
- 期：1
- 全文大小：1,603 KB
- 刊物主题：Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology;
- 出版者：Springer Berlin Heidelberg
- ISSN：2191-219X
文摘
Background The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery.