Diagnostic accuracy of 68Ga-DOTANOC PET/CT imaging in pheochromocytoma

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• 作者：Punit Sharma (1)
  Varun Singh Dhull (1)
  Saurabh Arora (1)
  Poonam Gupta (2)
  Rajeev Kumar (1)
  Prashant Durgapal (3)
  Arun Malhotra (1)
  Sunil Chumber (4)
  Ariachery C. Ammini (2)
  Rakesh Kumar (1)
  Chandrasekhar Bal (1)
  
• 关键词：Pheochromocytoma ; 68Ga ; DOTANOC ; PET/CT ; MIBG
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：41
• 期：3
• 页码：494-504
• 全文大小：464 KB
• 作者单位：Punit Sharma (1)
  Varun Singh Dhull (1)
  Saurabh Arora (1)
  Poonam Gupta (2)
  Rajeev Kumar (1)
  Prashant Durgapal (3)
  Arun Malhotra (1)
  Sunil Chumber (4)
  Ariachery C. Ammini (2)
  Rakesh Kumar (1)
  Chandrasekhar Bal (1)
  
  1. Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
  2. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
  3. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
  4. Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India
  
• ISSN：1619-7089

文摘

Purpose The purpose of the present study was to evaluate the diagnostic accuracy of 68Ga-DOTANOC positron emission tomography (PET)/CT in patients with suspicion of pheochromocytoma. Methods Data of 62 patients [age 34.3?±-6.1?years, 14 with multiple endocrine neoplasia type 2 (MEN2)] with clinical/biochemical suspicion of pheochromocytoma and suspicious adrenal lesion on contrast CT (n--0), who had undergone 68Ga-DOTANOC PET/CT, were retrospectively analyzed. PET/CT images were analyzed visually as well as semiquantitatively, with measurement of maximum standardized uptake value (SUVmax), SUVmean, SUVmax/SUVliver, and SUVmean/SUVliver. Results of PET/CT were compared with 131I-metaiodobenzylguanidine (MIBG) imaging, which was available in 40 patients (45 lesions). Histopathology and/or imaging/clinical/biochemical follow-up (minimum 6?months) was used as reference standard. Results The sensitivity, specificity, and accuracy of 68Ga-DOTANOC PET/CT was 90.4, 85, and 88.7?%, respectively, on patient-based analysis and 92, 85, and 90?%, respectively, on lesion-based analysis. 68Ga-DOTANOC PET/CT showed 100?% accuracy in patients with MEN2 syndrome and malignant pheochromocytoma. On direct comparison, lesion-based accuracy of 68Ga-DOTANOC PET/CT for pheochromocytoma was significantly higher than 131I-MIBG imaging (91.1 vs 66.6?%, p--.035). SUVmax was higher for pheochromocytomas than other adrenal lesions (p--.005), MEN2-associated vs sporadic pheochromocytoma (p--.012), but no difference was seen between benign vs malignant pheochromocytoma (p--.269). Conclusion 68Ga-DOTANOC PET/CT shows high diagnostic accuracy in patients with suspicion of pheochromocytoma and is superior to 131I-MIBG imaging for this purpose. Best results of 68Ga-DOTANOC PET/CT are seen in patients with MEN2-associated and malignant pheochromocytoma.