Association between nuclear expression of retinoic acid receptor alpha and beta and clinicopathological features and prognosis of advanced non-small cell lung cancer
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- 作者：Saé Muñiz-Hernández ; Sara Huerta-Yepez…
- 关键词：Retinoic acid receptor ; YY1 transcription factor ; Biomarker ; Non ; small cell lung cancer ; Platinum ; based doublet chemotherapy
- 刊名：International Journal of Clinical Oncology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：21
- 期：6
- 页码：1051-1061
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Surgical Oncology; Cancer Research;
- 出版者：Springer Japan
- ISSN：1437-7772
- 卷排序：21
文摘
BackgroundTranscription factors such as retinoic acid receptor alpha (RARα) and beta (RARβ) and Yin Yang 1 (YY1) are associated with the progression of non-small cell lung cancer (NSCLC). In particular, a lack of RARβ expression is associated with NSCLC development. The aim of this study was to analyze the expression of RARα, RARβ and YY1 and their relationship with prognosis in patients with advanced NSCLC.