Dendritic cells as gatekeepers of tolerance

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• 作者：Ari Waisman ; Dominika Lukas ; Björn E. Clausen ; Nir Yogev
• 关键词：Tolerance induction ; Dendritic cells ; Regulatory T cells
• 刊名：Seminars in Immunopathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：39
• 期：2
• 页码：153-163
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Internal Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2300
• 卷排序：39

文摘

Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune responses. In particular, they are considered as the most potent antigen presenting cells, governing both T cell immunity and tolerance. In view of their exceptional ability to present antigen and to interact with T cells, DC play distinct roles in shaping T cell development, differentiation and function. The outcome of the DC-T cell interaction is determined by the state of DC maturation, the type of DC subset, the cytokine microenvironment and the tissue location. Both regulatory T cells (Tregs) and DC are indispensable for maintaining central and peripheral tolerance. Over the past decade, accumulating data indicate that DC critically contribute to Treg differentiation and homeostasis.