Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents

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• 作者：Giordano de Guglielmo ; Marsida Kallupi ; Giulia Scuppa…
• 关键词：Addiction ; Heroin ; Pioglitazone ; Withdrawal ; Relapse ; Yohimbine ; Cues ; Priming
• 刊名：Psychopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：234
• 期：2
• 页码：223-234
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2072
• 卷排序：234

文摘

RationaleRelapse to opioids is often driven by the avoidance of the aversive states of opioid withdrawal. We recently demonstrated that activation of peroxisome proliferator-activated receptor gamma (PPARγ) by pioglitazone reduces the motivation for heroin and attenuates its rewarding properties. However, the role of PPARγ in withdrawal and other forms of relapse to heroin is unknown.