Meta-analysis of gene expression in relapsed childhood B-acute lymphoblastic leukemia
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- 作者：Yock-Ping Chow ; Hamidah Alias ; Rahman Jamal
- 关键词：Pediatric B ; acute lymphoblastic leukemia ; Relapse ; Microarray ; Gene expression
- 刊名：BMC Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：1282KB
- 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1471-2407
- 卷排序：17
文摘
BackgroundRelapsed pediatric B-acute lymphoblastic leukemia (B-ALL) remains as the leading cause of cancer death among children. Other than stem cell transplantation and intensified chemotherapy, no other improved treatment strategies have been approved clinically. Gene expression profiling represents a powerful approach to identify potential biomarkers and new therapeutic targets for various diseases including leukemias. However, inadequate sample size in many individual experiments has failed to provide adequate study power to yield translatable findings. With the hope of getting new insights into the biological mechanisms underpinning relapsed ALL and identifying more promising biomarkers or therapeutic targets, we conducted a meta-analysis of gene expression studies involving ALL from 3 separate studies.