Evaluation of repolarization dynamics using the QT–RR regression line slope and intercept relationship during 24-h Holter ECG

详细信息    查看全文

• 作者：Akira Fujiki ; Ryozo Yoshioka ; Masao Sakabe
• 关键词：Idiopathic ventricular fibrillation ; Long QT syndrome ; QT interval ; QT–RR relation ; Torsades de pointes
• 刊名：Heart and Vessels
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：30
• 期：2
• 页码：235-240
• 全文大小：661 KB
• 参考文献：1. Merri, M, Moss, AJ, Benhorin, J, Locati, EH, Alberti, M, Badilini, F (1992) Relation between ventricular repolarization duration and cardiac cycle length during 24-Holter recordings: findings in normal patients and with long QT syndrome. Circulation 85: pp. 1816-1821 CrossRef
  2. Iacoviello, M, Forleo, C, Guida, P, Romito, R, Sorgente, A, Sorrentino, S, Catucci, S, Mastropasqua, F, Pitzalis, M (2007) Ventricular repolarization dynamicity provides independent prognostic information toward major arrhythmic events in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 50: pp. 225-231 CrossRef
  3. Indik, JH, Pearson, EC, Fried, K, Woosley, RL (2006) Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval. Heart Rhythm 3: pp. 1003-1007 CrossRef
  4. Viskin, S (2009) The QT interval: too long, too short or just right. Heart Rhythm 6: pp. 711-715 CrossRef
  5. Smetana, P, Pueyo, E, Hnatkova, K, Batchvarov, V, Laguna, P, Malik, M (2004) Individual patterns of dynamic QT/RR relationship in survivors of acute myocardial infarction and their relationship to antiarrhythmic efficacy of amiodarone. J Cardiovasc Electrophysiol 15: pp. 1147-1154 CrossRef
  6. Watanabe, E, Arakawa, T, Uchiyama, T, Tong, M, Yasui, K, Takeuchi, H, Terasawa, T, Kodama, I, Hishida, H (2007) Prognostic significance of circadian variability of RR and QT intervals and QT dynamicity in patients with chronic heart failure. Heart Rhythm 4: pp. 999-1005 CrossRef
  7. Cygankiewicz, I, Zareba, W, Vazquez, R, Almendral, J, Bayes-Genis, A, Fiol, M, Valdes, M, Macaya, C, Gonzalez-Juanatey, JR, Cinca, J, Bayes de Luna, A (2008) Prognostic value of QT/RR slope in predicting mortality in patients with congestive heart failure. J Cardiovasc Electrophysiol 19: pp. 1066-1072 CrossRef
  8. Malik, M, F?rbom, P, Batchvarov, V, Hnatkova, K, Camm, AJ (2002) Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval. Heart 87: pp. 220-228 CrossRef
  9. Fujiki, A, Sakabe, M (2011) Comparison of QT/RR relation based on a 15-s averaged ECG and a single beat ECG during atrial fibrillation. Circ J 75: pp. 274-279 CrossRef
  10. Emori, T, Ohe, T, Aihara, N, Shimizu, W, Kamakura, S, Shimomura, K (1995) Dynamic relationship between the QaT interval and heart rate in patients with long QT syndrome during 24-hour Holter ECG monitoring. Pacing Clin Electrophysiol 18: pp. 1909-1918 CrossRef
  11. Suto, F, Zhu, W, Chan, A, Gross, GJ (2007) IKr and IKs remodeling differentially affects QT interval prolongation and dynamic adaptation to heart rate acceleration in bradycardic rabbits. Am J Physiol Heart Circ Physiol 292: pp. H1782-H1788 CrossRef
  12. Nakashima, K, Kusakawa, I, Yamamoto, T, Hirabayashi, S, Hosoya, R, Shimizu, W, Sumitomo, N (2013) A left ventricular noncompaction in a patient with long QT syndrome caused by a KCNQ1 mutation: a case report. Heart Vessels 28: pp. 126-129 CrossRef
  13. Bando, S, Soeki, T, Matsuura, T, Niki, T, Ise, T, Yamaguchi, K, Taketani, Y, Iwase, T, Yamada, H, Wakatsuki, T, Akaike, M, Aiba, T, Shimizu, W, Sata, M (2013) Congenital long QT syndrome with compound mutations in the KCNH2 gene. Heart Vessels.
  14. Takenaka, K, Ai, T, Shimizu, W, Ninomiya, T, Otani, H, Kubota, T, Takaki, H, Kamakura, S, Horie, M (2003) Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  Biomedical Engineering
  Interventional Radiology
  Ultrasound
  
• 出版者：Springer Japan
• ISSN：1615-2573

文摘

QT–RR linear regression consists of two parameters, slope and intercept, and the aim of this study was to evaluate repolarization dynamics using the QT–RR linear regression slope and intercept relationship during 24-h Holter ECG. This study included 466 healthy subjects (54.6?±?14.6?years; 200 men and 266 women) and 17 patients with ventricular arrhythmias, consisted of 10 patients with idiopathic ventricular fibrillation (IVF) and 7 patients with torsades de pointes (TDP). QT and RR intervals were measured from ECG waves based on a 15-s averaged ECG during 24-h Holter recording using an automatic QT analyzing system. The QT interval dependence on the RR interval was analyzed using a linear regression line for each subject ([QT]?=?A[RR]?+?B; where A is the slope and B is the y-intercept). The slope of the QT–RR regression line in healthy subjects was significantly greater in women than in men (0.185?±?0.036 vs. 0.161?±?0.033, p?p?B?=??.62A?+?0.34, r?=??.79). Distribution of both scatter diagrams of the slope and the intercept of the QT–RR regression line in patients with IVF and TDP was different from healthy subjects (left corner for IVF and upward shift for TDP). The slope and intercept relationship of the QT–RR linear regression line based on 24-h Holter ECG may become a simple useful marker for abnormality of ventricular repolarization dynamics.