Occurrences, mechanism of action, structural activity relationship and various pharmacological activities of thiadiazole and their derivatives

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• 作者：C. Gopi ; V. G. Sastry ; M. D. Dhanaraju
• 刊名：Review Journal of Chemistry
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：6
• 期：3
• 页码：177-217
• 全文大小：1,920 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Russian Library of Science
  Chemistry
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：2079-9799
• 卷排序：6

文摘

In the recent times, many people around the world are suffering drug resistant in most of the antibiotics used in different circumferences. In order to overcome the antibiotic resistance problem, there is need to use of existing antibiotics consciously and prepare novel compounds which exhibit high therapeutic profile against different pathogens with least resistance. In this review we discussed the thiadiazole derivatives and their different biological activities such as anti-inflammatory, anti-helicobacter pylori, anti-microbial, anti-cancer, antiviral, anti-depressant, analgesic, herbicidal and adenosine A3 receptor inhibitor, besides that this review also provides a detailed information about structural activity relationship (SAR) of such a compounds prepared by different medicinal chemist to date. In general, SAR is the smartest tool among the medicinal chemist to create a better therapeutic efficacy and high safety bioactive molecule in a short span of time. Besides that, we pointed out here different challenges of thiadiazole derivatives and its feature perspectives.KeywordsAnti-bioticsDrug resistantPharmacological activitiesStructural activity relationshipSafety and efficacy