The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice

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• 作者：Sylvie Casteras ; Aya Abdul-Wahed ; Maud Soty ; Fanny Vulin ; Hervé Guillou…
• 关键词：Adipose tissue ; Fatty acids ; Glucose 6 ; phosphatase ; Hepatic glucose production ; Hepatokines ; Insulin resistance ; Liver ; Obesity ; Steatosis
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：59
• 期：12
• 页码：2645-2653
• 全文大小：805 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428
• 卷排序：59

文摘

Aims/hypothesisDespite the strong correlation between non-alcoholic fatty liver disease and insulin resistance, hepatic steatosis is associated with greater whole-body insulin sensitivity in several models. We previously reported that the inhibition of hepatic glucose production (HGP) protects against the development of obesity and diabetes despite severe steatosis, thanks to the secretion of specific hepatokines such as fibroblast growth factor 21 (FGF21) and angiopoietin-related growth factor. In this work, we focused on adipose tissue to assess whether liver metabolic fluxes might, by interorgan communication, control insulin signalling in lean animals.