Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells
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- 作者：Akiko Okuda ; Suguru Kurokawa ; Masanori Takehashi ; Aika Maeda…
- 关键词：Poly(ADP ; ribosyl)ation ; Poly(ADP ; ribose) polymerase ; Neural stem/progenitor cells ; p53 ; Cell cycle ; Apoptosis
- 刊名：BMC Neuroscience
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：2922KB
- 刊物主题：Neurosciences; Neurobiology; Animal Models;
- 出版者：BioMed Central
- ISSN：1471-2202
- 卷排序：18
文摘
BackgroundPoly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcription. Recently, PARP-1 was reported to participate in the somatic cell reprogramming process. Previously, we revealed a role for PARP-1 in the induction of neural apoptosis in a cellular model of cerebral ischemia and suggested the possible use of PARP inhibitors as a new therapeutic intervention. In the present study, we examined the effects of PARP inhibitors on neural stem/progenitor cells (NSPCs) of the mouse brain.