Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection
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- 作者：Wilmar de Graaf (1)
Krijn P. van Lienden (2)
Sander Dinant (1)
Joris J. T. H. Roelofs (3)
Olivier R. C. Busch (1)
Dirk J. Gouma (1)
Roelof J. Bennink (4)
Thomas M. van Gulik (1) - 关键词：Hepatectomy ; Liver failure ; Liver function ; Liver volume ; Mebrofenin ; CT volumetry
- 刊名：Journal of Gastrointestinal Surgery
- 出版年：2010
- 出版时间：February 2010
- 年：2010
- 卷：14
- 期：2
- 页码：369-378
- 全文大小：261KB
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Krijn P. van Lienden (2)
Sander Dinant (1)
Joris J. T. H. Roelofs (3)
Olivier R. C. Busch (1)
Dirk J. Gouma (1)
Roelof J. Bennink (4)
Thomas M. van Gulik (1)
1. Department of Surgery, Academic Medical Center, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands
2. Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
3. Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
4. Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
文摘
Background 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) was used as a quantitative method to evaluate liver function. The aim of this study was to compare future remnant liver function assessed by 99mTc-mebrofenin hepatobiliary scintigraphy with future remnant liver volume in the prediction of liver failure after major liver resection. Methods Computed tomography (CT) volumetry and 99mTc-mebrofenin hepatobiliary scintigraphy were performed prior to major resection in 55 high-risk patients, including 30 patients with parenchymal liver disease. Liver volume was expressed as percentage of total liver volume or as standardized future remnant liver volume. Receiver operating characteristic (ROC) curve analysis was performed to identify a cutoff value for future remnant liver function in predicting postoperative liver failure. Results Postoperative liver failure occurred in nine patients. A liver function cutoff value of 2.69%/min/m2 was calculated by ROC curve analysis. 99mTc-mebrofenin hepatobiliary scintigraphy demonstrated better sensitivity, specificity, and positive and negative predictive value compared to future remnant liver volume. Using 99mTc-mebrofenin hepatobiliary scintigraphy, one cutoff value suffices in both compromised and noncompromised patients. Conclusion Preoperative 99mTc-mebrofenin hepatobiliary scintigraphy is a valuable technique to estimate the risk of postoperative liver failure. Especially in patients with uncertain quality of the liver parenchyma, 99mTc-mebrofenin HBS proved of more value than CT volumetry.