T. gondii rhoptry protein ROP18 induces apoptosis of neural cells via endoplasmic reticulum stress pathway
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- 作者：Lijuan Wan ; Lingli Gong ; Wei Wang ; Ran An ; Meijuan Zheng…
- 关键词：T. gondii ; ROP18 ; ER stress ; Apoptosis
- 刊名：Parasites & Vectors
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：8
- 期：1
- 全文大小：2,522 KB
- 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine; Entomology;
- 出版者：BioMed Central
- ISSN：1756-3305
文摘
Background The neurotropic parasite T. gondii is widespread among mammalian hosts including humans. During the course of T. gondii infection, the central nervous system is the most commonly damaged of all invasive organs. The polymorphic rhoptry protein ROP18 has been identified as a key factor in the pathogenesis of T. gondii; however, the molecular mechanism by which this protein exerts neuropathogenesis remains elusive.