The ROVIGO Study (Risk of Vascular Complications: Impact of Genetics in Old people): Protocol, Study Design, and Preliminary Results of the Initial Survey

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• 作者：Alberto Mazza (1)
  Sergio Zamboni (2)
  Emilio Ramazzina (2)
  Laura Schiavon (2)
  Panagiota Rempelou (3)
  Sara Zorzan (2)
  Anna Bascelli (3)
  Rosa Segato (2)
  Rossana Redi (2)
  Elisa Pagnin (3)
  Alessandro Camerotto (4)
  Marco Zuin (5)
  Enzo Rizzato (6)
  Adriano Marcolongo (7)
  Arturo Orsini (8)
  Domenico Rubello (9)
  Edoardo Casiglia (3)
  
  1. Hypertension Centre Certified by the Italian Society of Hypertension ; Santa Maria della Misericordia General Hospital ; Rovigo ; Italy
  2. Department of Internal Medicine ; Santa Maria della Misericordia General Hospital ; Rovigo ; Italy
  3. Department of Medicine ; University of Padova ; Padova ; Italy
  4. Laboratory of Medicine ; Department of Clinical Pathology ; Santa Maria della Misericordia General Hospital ; Rovigo ; Italy
  5. Faculty of Medicine ; University of Ferrara ; Ferrara ; Italy
  6. General Direction ; Santorso Hospital ; Local Health Unit No. 4 ; Thiene ; Italy
  7. General Direction ; Friuli Venezia Giulia ; Trieste ; Italy
  8. General Direction ; Santa Maria della Misericordia General Hospital ; Rovigo ; Italy
  9. Department of Nuclear Medicine ; Radiology ; NeuroRadiology ; Medical Physics ; Santa Maria della Misericordia General Hospital ; Rovigo ; Italy
  
• 关键词：Cardiovascular risk ; Epidemiology ; Elderly population ; Human
• 刊名：High Blood Pressure & Cardiovascular Prevention
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：22
• 期：1
• 页码：73-78
• 全文大小：242 KB
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• 刊物主题：Cardiology; Pharmacotherapy;
• 出版者：Springer International Publishing
• ISSN：1179-1985

文摘

Background The epidemiology of cardiovascular risk (CV) in the elderly is far from being defined, and the reasons why some subjects retain a healthy body while growing old while others are affected by different diseases or die prematurely are still unknown. Aims To compare the CV risk pattern in two elderly cohorts living in North-East Italy. Materials and methods The Risk Of Vascular complications: Impact of Genetics in Old people (ROVIGO) study is a population-based study including 580 unrelated elderly subjects representative of general population living in Rovigo in the Veneto region. They were compared to a cohort of 580 age-gender-matched unrelated subjects from the CArdiovascular STudy in the Elderly (CASTEL) living in the same region in Castelfranco Veneto and Chioggia. Results Blood pressure (BP), heart rate (HR), low-density-lipoprotein cholesterol, and prevalence of coronary heart disease, heart failure and chronic pulmonary disease were lower in the ROVIGO than in the CASTEL cohort, while high-density-lipoprotein cholesterol and the prevalence of diabetes were higher in the former than in the latter. In the ROVIGO cohort, diabetes, left ventricular hypertrophy, coronary and cerebrovascular diseases were more represented in men. In the CASTEL cohort, systolic BP was higher in women. In both cohorts, the lipid pattern was less favourable and HR higher in women, chronic pulmonary disease more represented in men. Conclusions People living in Rovigo were at lower CV risk than those in Castelfranco Veneto and Chioggia, mainly due to lower BP values, better lipid pattern and lower prevalence of CV and pulmonary disease.