B-Zell-Therapie mit Rituximab bei rheumatoider Arthritis

详细信息    查看全文

• 作者：Dr. M. Schmalzing (1)
  H.-P. Tony (1)
  
  1. Medizinische Klinik und Poliklinik II ; Rheumatologie/Klinische Immunologie ; Universit盲tsklinikum W眉rzburg ; Oberd眉rrbacher Str. 6 ; 97080 ; W眉rzburg ; Deutschland
  
• 关键词：B ; Zellen ; ANCA ; assoziierte Vaskulitiden ; Mikroskopische Polyangiitis ; Granulomatose mit Polyangiitis ; Autoimmunerkrankungen ; B cells ; ANCA ; associated vasculitis ; Microscopic polyangiitis ; Granulomatosis with polyangiitis ; Autoimmune diseases
• 刊名：Zeitschrift f篓鹿r Rheumatologie
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：74
• 期：3
• 页码：250-257
• 全文大小：519 KB
• 参考文献：1. Chatzidionysiou, (2011) Ann Rheum Dis 70: pp. 1575 6/ard.2010.148759" target="_blank" title="It opens in new window">CrossRef
  2. Chatzidionysiou, (2012) Ann Rheum Dis 71: pp. 374 6/annrheumdis-2011-200003" target="_blank" title="It opens in new window">CrossRef
  3. Devauchelle-Pensec, (2014) Ann Intern Med 160: pp. 233 6/M13-1085" target="_blank" title="It opens in new window">CrossRef
  4. D枚rner, (2003) Curr Opin Rheumatol 15: pp. 246 CrossRef
  5. Engel, (2011) Pharmacol Rev 63: pp. 127 6" target="_blank" title="It opens in new window">CrossRef
  6. Emery, (2011) Rheumatology 50: pp. 2223 CrossRef
  7. Emery P, Gottenberg JE, Rubbert-Roth A (2014) Rituximab versus an alternative TNF inhibitor in patients with rheumatoid arthritis who failed to respond to a single previous TNF inhibitor: SWITCH-RA, a global, observational, comparative effectiveness study. Ann Rheum Dis. doi:10.1136/annrheumdis-2013-203993 [Epub ahead of print]
  8. Favalli EG, Biggioggero M, Marchesoni A, Meroni PL (2014) Survival on treatment with second-line biologic therapy: a cohort study comparing cycling and swap strategies. Rheumatology (Oxford) 53:1664鈥?668
  9. Fachinformation MabThera, Stand Mai 2014
  10. Finckh, (2007) Ann Rheum Dis 66: pp. 123 6/ard.2006.065060" target="_blank" title="It opens in new window">CrossRef
  11. Finckh, (2007) Arthritis Rheum 56: pp. 1417 CrossRef
  12. Goldacker, (2013) Z Rheumatol 72: pp. 690 CrossRef
  13. Gottenberg, (2013) Arthritis Rheum 65: pp. S606
  14. Kekow, (2012) Biologics 6: pp. 191
  15. Keystone, (2012) Rheumatol 39: pp. 2238
  16. Kr眉ger, (2012) Z Rheumatol 71: pp. 592 CrossRef
  17. Merrill, (2010) Arthritis Rheum 62: pp. 222 CrossRef
  18. Mitteilung der St盲ndigen Impfkommission (STIKO) am Robert Koch-Institut. Hinweise zu Impfungen f眉r Patienten mit Immundefizienz. Stand: November 2005
  19. Panayi GS (2005) B-cells: a fundamental role in the pathogenesis of rheumatoid arthritis? Rheumatology (Oxford) 44(Suppl 1):ii3鈥搃i7
  20. Pritchard, (2014) BMC Musculoskelet Disord 15: pp. 177 6/1471-2474-15-177" target="_blank" title="It opens in new window">CrossRef
  21. Roll, (2009) Z Rheumatol 68: pp. 255 6" target="_blank" title="It opens in new window">CrossRef
  22. Rubbert-Roth, (2014) Z Rheumatol 73: pp. 165 CrossRef
  23. Schmalzing, (2014) Akt Rheumatol 39: pp. 160 64" target="_blank" title="It opens in new window">CrossRef
  24. Singh, (2012) Arthritis Care Res: pp. 625 641" target="_blank" title="It opens in new window">CrossRef
  25. Stashenko, (1980) J Immunol 125: pp. 1678
  26. Strangfeld, (2013) Arthritis Rheum 65: pp. 06
  27. Vollenhoven, (2013) Arthritis Rheum 65: pp. 2342
  28. Wendler, (2014) Arthritis Res Ther 16: pp. R80 6/ar4521" target="_blank" title="It opens in new window">CrossRef
  
• 刊物主题：Internal Medicine; Rheumatology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1250

文摘

Background B cells play a key role in the pathogenesis of various rheumatic autoimmune diseases and have therefore become an important therapeutic target. Rituximab is a chimeric monoclonal anti-CD20 antibody that induces a nearly complete, transient depletion of peripheral CD20-positive B cells. In 2006 rituximab received approval for use in patients with rheumatoid arthritis (RA) and in 2013 for patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Objectives In this review various clinically relevant aspects of B cell therapy in RA patients are discussed, including its role in the therapeutic algorithm as well as data on long-term efficacy and safety.