Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells

详细信息    查看全文

• 作者：T. N. Portseva ; A. V. Brechalov ; E. A. Dukhanina…
• 刊名：Doklady Biochemistry and Biophysics
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：467
• 期：1
• 页码：121-123
• 全文大小：506 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Biophysics and Biomedical Physics
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3091
• 卷排序：467

文摘

The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion. These findings extend our understanding of the molecular mechanisms of the tumorigenic effect of Oct-1.Original Russian Text © T.N. Portseva, A.V. Brechalov, E.A. Dukhanina, A.G. Stepchenko, E.V. Pankratova, S.G. Georgieva, 2016, published in Doklady Akademii Nauk, 2016, Vol. 467, No. 4, pp. 481–483.Presented by Academician Yu. V. Il’in November 9, 2015