Multiscale fingerprinting of neuronal functional connectivity

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• 作者：Gang Song ; Chung Tin ; Chi-Sang Poon
• 关键词：Multiscale fingerprinting ; Functional connectivity ; Pneumotaxic center ; K?lliker ; Fuse nucleus ; Pons ; Post ; inspiratory activity ; Respiratory rhythm ; Laryngeal motoneurons
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：220
• 期：5
• 页码：2967-2982
• 全文大小：4,764 KB
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  MacDonald SM, Tin C, Song G
• 作者单位：Gang Song (1)
  Chung Tin (1) (2)
  Chi-Sang Poon (1)
  
  1. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
  2. Department of Mechanical and Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong, China
  
• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

Current cellular-based connectomics approaches aim to delineate the functional or structural organizations of mammalian brain circuits through neuronal activity mapping and/or axonal tracing. To discern possible connectivity between functionally identified neurons in widely distributed brain circuits, reliable and efficient network-based approaches of cross-registering or cross-correlating such functional-structural data are essential. Here, a novel cross-correlation approach that exploits multiple timing-specific, response-specific, and cell-specific neuronal characteristics as coincident fingerprint markers at the systems, network, and cellular levels is proposed. Application of this multiscale temporal-cellular coincident fingerprinting assay to the respiratory central pattern generator network in rats revealed a descending excitatory pathway with characteristic activity pattern and projecting from a distinct neuronal population in pons to its counterparts in medulla that control the post-inspiratory phase of the respiratory rhythm important for normal breathing, airway protection, and respiratory-vocalization coordination. This enabling neurotracing approach may prove valuable for functional connectivity mapping of other brain circuits. Keywords Multiscale fingerprinting Functional connectivity Pneumotaxic center K?lliker-Fuse nucleus Pons Post-inspiratory activity Respiratory rhythm Laryngeal motoneurons