Macrophage density and macrophage colony-stimulating factor expression predict the postoperative prognosis in patients with intrahepatic cholangiocarcinoma

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• 作者：Kosuke Oishi ; Takanori Sakaguchi ; Satoshi Baba ; Shohachi Suzuki…
• 关键词：Intrahepatic cholangiocarcinoma ; Macrophage density ; Macrophage colony ; stimulating factor ; Hepatectomy
• 刊名：Surgery Today
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：45
• 期：6
• 页码：715-722
• 全文大小：1,609 KB
• 参考文献：1.The Liver Cancer Group of Japan. Primary liver cancer in Japan. Ann Surg. 1990;211:277-7.
  2.Ikai I, Okazaki M, Okita L, et al. Report of the 17th Nationwide follow-up survey of primary liver cancer in Japan. Hepatol Res. 2007;39:676-1.View Article
  3.Welzel TM, Graubard BI, El-Serag HB. Risk factors for intra- and extrahepatic cholangiocarcinoma in the United States: a population based case-control study. Clin Gastroenterol Hepatol. 2007;5:1221-.View Article PubMed Central PubMed
  4.Gatto M, Alvaro D. Cholangiocarcinoma: risk factors and clinical presentation. Eur Rev Med Pharmacol Sci. 2010;14:363-.PubMed
  5.Hasita H, Komohara Y, Okabe H, et al. Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma. Cancer Sci. 2010;101(8):1913-.View Article PubMed
  6.Ding T, Xu J, Wang F, et al. High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. Hum Pathol. 2009;40:381-.View Article PubMed
  7.Li YW, Qiu SJ, Fan J, et al. Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection. J Cancer Res Clin Oncol. 2009;135(3):439-9.View Article PubMed
  8.Ohno S, Hiroyuki I, Dhar DJ, et al. The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival gastric cancer patients. Anticancer Res. 2003;23:5015-2.PubMed
  9.Forssell J, Oberg A, Henriksson ML. High macrophage infiltration along the tumor front correlates with improved survival in colon cancer. Clin Cancer Res. 2007;13(5):1472-.View Article PubMed
  10.Ohno S, Ohno Y, Suzuki N, et al. Correlation of histological localization of tumor-associated macrophages with clinicopathological features in endometrial cancer. Anticancer Res. 2004;24:3335-2.PubMed
  11.Bij GJ, Bogels M, Oosterling SJ, et al. Tumor infiltrating macrophages reduce development of peritoneal colorectal carcinoma metastases. Cancer Lett. 2008;262:77-6.View Article PubMed
  12.Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 2006;66(2):605-2.View Article PubMed
  13.Mantovani A, Sozzani S, Locati M, et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002;23(11):549-5.View Article PubMed
  14.Ma J, Liu L, Che G, et al. The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer. 2010;10:112.View Article PubMed Central PubMed
  15.Komohara Y, Ohnishi K, Kuratsu J, et al. Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol. 2008;216:15-4.View Article PubMed
  16.Niino D, Komohara Y, Murayama T, et al. Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL). Pathol Int. 2010;60:278-3.View Article PubMed
  17.Laoui D, Movahedi K, Overmeire EV, et al. Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions. Int J Dev Biol. 2011;55:861-.View Article PubMed
  18.Zhang B, Yac G, Zhang Y, et al. M2-Polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma. Clinics. 2011;66:1879-6.View Article PubMed Central PubMed
  19.Zhu XD, Zhang JB, Zhuang PY, et al. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol. 2008;26(16):2707-6.View Article PubMed
  20.Toy EP, Chambers JT, Kaminski BM, et al. The activated macrophage colony-stimulating factor (CSF-1) receptor as a predictor of poor outcome in advanced epithelial ovarian carcinoma. Gynecol Oncol. 2001;80:194-00.View Article PubMed
  21.Beck AH, Espinosa I, Edris B, et al. The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Clin Cancer Res. 2009;15:778-7.View Article PubMed Central PubMed
  22.Corzo CA, Condamine T, Lu L, et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. 2010;207:2439-3.View Article PubMed Central PubMed
  23.Takeda N, O’Dea EL, Doedens A, et al. Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis. Genes Dev. 2010;24:491-01.View Article PubMed Central PubMed
  24.Mason RP, Antich PP, Babcock EE, et al. Non-invasive determination of tumor oxygen tension and local variation with growth. Int J Radiat Oncol Biol Phys. 1994;29:95-03.View Article PubMed
  25.Sobin LH, Wittekind C. TNM classification of malignant tumours, 6th edn. New Jersey: John Wiley & Sons; 2002. pp. 114-17.
  26.Sica A, Larghi P, Mancino A, et al. Macrophage polarization
• 作者单位：Kosuke Oishi (1) (4)
  Takanori Sakaguchi (1)
  Satoshi Baba (2)
  Shohachi Suzuki (3)
  Hiroyuki Konno (1)
  
  1. Second Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan
  4. Kikugawa City Hospital, 1632 Higashiyokochi, Kikugawa, 439-0022, Japan
  2. Faculty of Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan
  3. Department of Surgery, Iwata City Hospital, 512-3 Okubo, Iwata, 438-8550, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Abdominal Surgery
  Thoracic Surgery
  Vascular Surgery
  Cardiac Surgery
  Surgical Oncology
  
• 出版者：Springer Japan
• ISSN：1436-2813

文摘

Purposes Macrophages are included in the stromal compartments in various neoplasms, and their behavior against tumors is diverse. The aim of this study was to examine the role of tumor-infiltrating macrophages and their main regulator, macrophage colony-stimulating factor (M-CSF), in intrahepatic cholangiocarcinoma (ICC). Methods Macrophage density and M-CSF expression in 39 resected ICC specimens were immunohistochemically evaluated in the central and peripheral areas of tumors, which were defined as fields more than and within 500?μm from the invasive front, respectively. The number of CD68-positive macrophages was counted using an image-analyzing software program. The relationship between these results and other clinicopathological factors and the postoperative prognosis were evaluated. Results Sporadic M-CSF expression in cancer cells around the peripheral area was observed in fourteen patients. M-CSF-positive ICCs showed a higher macrophage density in the tumor-peripheral area than did M-CSF-negative ICCs. M-CSF expression and higher macrophage density in the tumor-peripheral area were related to a better postoperative prognosis, whereas a higher macrophage density in the central area was one of the significant risk factors for a poor prognosis in a univariate analysis. Conclusion Tumor-peripheral macrophage infiltration, presumably dependent on M-CSF, and M-CSF-independent tumor-central macrophage infiltration are predictive factors for better and worse postoperative prognosis in ICC patients, respectively. The tumor microenvironment, such as the presence of hypoxia, may affect the behavior of infiltrating macrophages in ICC.