Novel biophysical determination of miRNAs related to prostate and head and neck cancers

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• 作者：Kristyna Hudcova (1) (4)
  Libuse Trnkova (2) (4)
  Iva Kejnovska (3) (5)
  Michaela Vorlickova (3) (5)
  Jaromir Gumulec (1) (4)
  Rene Kizek (4)
  Michal Masarik (1) (4)
  
  1. Department of Pathological Physiology ; Faculty of Medicine ; Masaryk University ; Kamenice 5 ; 625 00 ; Brno ; Czech Republic
  4. CEITEC ; Brno University of Technology ; Technicka 3058/10 ; 616 00 ; Brno ; Czech Republic
  2. Department of Chemistry ; Faculty of Science ; Masaryk University ; Kamenice 5 ; 625 00 ; Brno ; Czech Republic
  3. Institute of Biophysics v.v.i. ; Academy of Sciences of the Czech Republic ; Kralovopolska 135 ; 612 65 ; Brno ; Czech Republic
  5. CEITEC ; Masaryk University ; Kamenice 5 ; 625 00 ; Brno ; Czech Republic
  
• 关键词：miRNA ; Circular dichroism ; Electrochemistry ; Prostate cancer ; Head and neck cancer
• 刊名：European Biophysics Journal
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：44
• 期：3
• 页码：131-138
• 全文大小：490 KB
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• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Biophysics and Biomedical Physics
  Cell Biology
  Biochemistry
  Plant Physiology
  Animal Physiology
  Neurobiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1017

文摘

In this study we have chosen a new approach and characterized three miRNAs (miR-23a, miR-34a and miR-320a) related to prostate cancer and head and neck cancer by spectral (circular dichroic and UV-absorption spectra) and electrochemical (voltammetry at graphite and mercury electrodes) methods. The spectral and voltammetric results, reflecting different nucleotide sequences of miRNAs, were complemented by the results of DNAs(U) having the same oligonucleotide sequences as miRNAs. The effect of the substitution of ribose for deoxyribose was shown and structural diversity was confirmed. The stability of RNA and DNA(U) was studied using CD and UV-absorption spectroscopy and melting points were calculated. MiRNA-320a with the highest content of guanine provided the highest melting point. With respect to the rapid progress of miRNA electrochemical sensors, our results will be useful for the research and development of sensitive, portable and time-efficient miRNA sensors, which will be able to diagnose cancer and other diseases.