Acute Phase Proteins and Stress Hormone Responses in Patients with Newly Diagnosed Active Pulmonary Tuberculosis

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• 作者：J. O. Opolot (1)
  A. J. Theron (2) (3)
  R. Anderson (2)
  C. Feldman (1)
  
  1. Division of Pulmonology ; Department of Internal Medicine ; Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences ; University of the Witwatersrand ; Johannesburg ; South Africa
  2. South African Medical Research Council Unit for Inflammation and Immunity ; Department of Immunology ; Faculty of Health Sciences ; University of Pretoria ; Pretoria ; South Africa
  3. Tshwane Academic Division of the National Health Laboratory Service ; Pretoria ; South Africa
  
• 关键词：Acute phase response ; Catecholamines ; Cortisol ; Stress hormones ; Tuberculosis
• 刊名：Lung
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：193
• 期：1
• 页码：13-18
• 全文大小：176 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pneumology and Respiratory System
  
• 出版者：Springer New York
• ISSN：1432-1750

文摘

Introduction Despite the high burden of disease, there have been surprisingly few studies of the acute phase and plasma catecholamine/cortisol stress hormone responses in patients with active pulmonary tuberculosis. We wished to document acute phase reactant and stress hormone responses in patients with newly diagnosed, active pulmonary tuberculosis and to compare these responses to those of a group of surgical/medical cases with conditions other than tuberculosis. Methods This was a prospective study of consecutive patients with newly diagnosed pulmonary tuberculosis, admitted to a tertiary hospital in Johannesburg, South Africa, documenting demographic, clinical, routine laboratory, acute phase protein and stress hormone responses relative to those of the control group. Results TB patients had a higher body temperature and pulse rate, as well as a platelet counts, ferritin, CRP and dopamine levels, with a tendency to higher cortisol levels compared to the control group. Conversely, they had a lower BMI, haemoglobin, leucocyte count, MCV and epinephrine levels than the control group. Conclusions Patients with active pulmonary tuberculosis were documented to mount an acute stress response which was more intense than that of a control group of patients with surgical/medical conditions other than tuberculosis.