Single-use thermoplastic microfluidic burst valves enabling on-chip reagent storage

详细信息    查看全文

• 作者：Omid D. Rahmanian ; Don L. DeVoe
• 关键词：Reagent storage ; Thermoplastic fabrication ; Orogenic fabrication ; Point ; of ; care detection ; Microfluidic valves
• 刊名：Microfluidics and Nanofluidics
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：18
• 期：5-6
• 页码：1045-1053
• 全文大小：1,184 KB
• 参考文献：Aguilera-Herrador EE, Cruz-Vera MM, Valc谩rcel MM (2010) Analytical connotations of point-of-care testing. Analyst 135:2220鈥?232. doi:10.鈥?039/鈥媍0an00307g View Article
  Beebe DJ, Moore JS, Bauer JM et al (2000) Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature 404:588鈥?90. doi:10.鈥?038/鈥?5007047 View Article
  Blazej RG, Kumaresan P, Mathies RA (2006) Microfabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing. Proc Natl Acad Sci USA 103:7240鈥?245. doi:10.鈥?073/鈥媝nas.鈥?602476103 View Article
  Chang LL, Pikal MJ (2009) Mechanisms of protein stabilization in the solid state. J Pharm Sci 98:2886鈥?908. doi:10.鈥?002/鈥媕ps.鈥?1825 View Article
  Chen G, Svec F, Knapp DR (2008) Light-actuated high pressure-resisting microvalve for on-chip flow control based on thermo-responsive nanostructured polymer. Lab Chip 8:1198鈥?204. doi:10.鈥?039/鈥媌803293a View Article
  Chen C-F, Liu J, Chang C-C, DeVoe DL (2009a) High-pressure on-chip mechanical valves for thermoplastic microfluidic devices. Lab Chip 9:3511. doi:10.鈥?039/鈥媌912014a View Article
  Chen CF, Liu J, Hromada LP et al (2009b) High-pressure needle interface for thermoplastic microfluidics. Lab Chip 9:50. doi:10.鈥?039/鈥媌812812j View Article
  Cleland JL, Lam X, Kendrick B, Yang J (2001) A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody. J Pharm Sci 90(3):310鈥?21
  Garcia-Cordero JL, Kurzbuch D, Benito-Lopez F et al (2010) Optically addressable single-use microfluidic valves by laser printer lithography. Lab Chip 10:2680. doi:10.鈥?039/鈥媍004980h View Article
  Gervais L, de Rooij N, Delamarche E (2011) Microfluidic diagnostic devices: microfluidic chips for point-of-care immunodiagnostics (Adv. Mater. 24/2011). Adv Mater 23:H208鈥揌208. doi:10.鈥?002/鈥媋dma.鈥?01190098 View Article
  Gorkin R, Park J, Siegrist J et al (2010) Centrifugal microfluidics for biomedical applications. Lab Chip 10:1758. doi:10.鈥?039/鈥媌924109d View Article
  Grover WH, Ivester RHC, Jensen EC, Mathies RA (2006) Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. Lab Chip 6:623鈥?31. doi:10.鈥?039/鈥媌518362f View Article
  Hoffmann J, Mark D, Lutz S et al (2010) Pre-storage of liquid reagents in glass ampoules for DNA extraction on a fully integrated lab-on-a-chip cartridge. Lab Chip 10:1480. doi:10.鈥?039/鈥媌926139g View Article
  Hosokawa K, Maeda R (2000) A pneumatically-actuated three-way microvalve fabricated with polydimethylsiloxane using the membrane transfer technique. J Micromech Microeng 10:415鈥?20. doi: 10.鈥?088/鈥?960-1317/鈥?0/鈥?/鈥?17
  Kuo C-H, Wang J-H, Lee G-B (2009) A microfabricated CE chip for DNA pre-concentration and separation utilizing a normally closed valve. Electrophoresis 30:3228鈥?235. doi:10.鈥?002/鈥媏lps.鈥?00900112 View Article
  Liu RH, Bonanno J, Yang J, Lenigk R (2004) Single-use, thermally actuated paraffin valves for microfluidic applications. JMEMS. doi:10.鈥?016/鈥媕.鈥媠nb.鈥?003.鈥?9.鈥?37
  Luo Q, Mutlu S, Gianchandani YB et al (2003) Monolithic valves for microfluidic chips based on thermoresponsive polymer gels. Electrophoresis 24:3694鈥?702. doi:10.鈥?002/鈥媏lps.鈥?00305577 View Article
  Madou M, Zoval J, Jia G et al (2006) Lab on a CD. Annu Rev Biomed Eng 8:601鈥?28. doi:10.鈥?146/鈥媋nnurev.鈥媌ioeng.鈥?.鈥?61505.鈥?95758 View Article
  Meyer JD, Nayar R, Manning MC (2009) Impact of bulking agents on the stability of a lyophilized monoclonal antibody. Eur J Pharm Sci 38:29鈥?8. doi:10.鈥?016/鈥媕.鈥媏jps.鈥?009.鈥?5.鈥?08 View Article
  Mosadegh B, Mosadegh B, Tavana H et al (2011) High-density fabrication of normally closed microfluidic valves by patterned deactivation of oxidized polydimethylsiloxane. Lab Chip 11:738鈥?42. doi:10.鈥?039/鈥婥0LC00112K View Article
  Oh KW, Ahn CH (2006) A review of microvalves. J Micromech Microeng 16:R13鈥揜39. doi:10.鈥?088/鈥?960-1317/鈥?6/鈥?/鈥婻01 View Article
  Park J-M, Cho Y-K, Lee BS et al (2007) Multifunctional microvalves control by optical illumination on nanoheaters and its application in centrifugal microfluidic devices. Lab Chip 7:557鈥?64. doi:10.鈥?039/鈥媌616112j View Article
  Rahmanian O, DeVoe DL (2013) Pen microfluidics: rapid desktop manufacturing of sealed thermoplastic microchannels. Lab Chip 13:1102鈥?108. doi:10.鈥?039/鈥婥2LC41057E View Article
  Rahmanian O, Chen C-F, DeVoe DL (2012) Microscale patterning of thermoplastic polymer surfaces by selective solvent swelling. Langmuir 28:12923鈥?2929. doi:10.鈥?021/鈥媗a302704t View Article
  Ramachandran S, Fu E, Lutz B, Yager P (2014) Long-term dry storage of an enzyme-based reagent system for ELISA in point-of-care devices. Analyst 139:1456鈥?462. doi:10.鈥?039/鈥媍3an02296j View Article
  Tsao C-W, DeVoe D (2009) Bonding of thermoplastic polymer microfluidics. Microfluid Nanofluidics 6:1鈥?6. doi:10.鈥?007/鈥媠10404-008-0361-x View Article
  Tsao CW, Hromada L, Liu J et al (2007) Low temperature bonding of PMMA and COC microfluidic substrates using UV/ozone surface treatment. Lab Chip 7:499鈥?05. doi:10.鈥?039/鈥媌618901f View Article
  van Oordt T, Barb Y, Smetana J et al (2013) Miniature stick-packaging鈥攁n industrial technology for pre-storage and release of reagents in lab-on-a-chip systems. Lab Chip 13:2888. doi:10.鈥?039/鈥媍3lc50404b View Article
  Yang Y-N, Hsiung S-K, Lee G-B (2009) A pneumatic micropump incorporated with a normally closed valve capable of generating a high pumping rate and a high back pressure. Microfluid Nanofluidics 6:823鈥?33. doi:10.鈥?007/鈥媠10404-008-0356-7 View Article
  
• 作者单位：Omid D. Rahmanian (1)
  Don L. DeVoe (1) (2)
  
  1. Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA
  2. Department of Mechanical Engineering, University of Maryland, College Park, MD, 20742, USA
  
• 刊物类别：Engineering
• 刊物主题：Engineering Fluid Dynamics
  Medical Microbiology
  Polymer Sciences
  Nanotechnology
  Mechanics, Fluids and Thermodynamics
  Engineering Thermodynamics and Transport Phenomena
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1613-4990

文摘

A simple and reliable method for fabricating single-use normally closed burst valves in thermoplastic microfluidic devices is presented, using a process flow that is readily integrated into established workflows for the fabrication of thermoplastic microfluidics. An experimental study of valve performance reveals the relationships between valve geometry and burst pressure. The technology is demonstrated in a device employing multiple valves engineered to actuate at different inlet pressures that can be generated using integrated screw pumps. On-chip storage and reconstitution of fluorescein salt sealed within defined reagent chambers are demonstrated. By taking advantage of the low gas and water permeability of cyclic olefin copolymer, the robust burst valves allow on-chip hermetic storage of reagents, making the technology well suited for the development of integrated and disposable assays for use at the point of care.