Yeast factories for the production of aromatic compounds: from building blocks to plant secondary metabolites
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- 作者：Miguel Suástegui ; Zengyi Shao
- 关键词：Metabolic engineering ; Aromatic amino acids ; Shikimic acid ; Flavonoids ; Stilbenoids ; Benzylisoquinoline alkaloids ; Saccharomyces cerevisiae
- 刊名：Journal of Industrial Microbiology and Biotechnology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：43
- 期：11
- 页码：1611-1624
- 全文大小：3,217 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Chemistry
Biotechnology
Genetic Engineering
Biochemistry
Bioinformatics
Microbiology
Microbial Genetics and Genomics - 出版者：Springer Berlin / Heidelberg
- ISSN：1476-5535
- 卷排序：43
文摘
The aromatic amino acid biosynthesis pathway is a source to a plethora of commercially relevant chemicals with very diverse industrial applications. Tremendous efforts in microbial engineering have led to the production of compounds ranging from small aromatic molecular building blocks all the way to intricate plant secondary metabolites. Particularly, the yeast Saccharomyces cerevisiae has been a great model organism given its superior capability to heterologously express long metabolic pathways, especially the ones containing cytochrome P450 enzymes. This review contains a collection of state-of-the-art metabolic engineering work devoted towards unraveling the mechanisms for enhancing the flux of carbon into the aromatic pathway. Some of the molecules discussed include the polymer precursor muconic acid, as well as important nutraceuticals (flavonoids and stilbenoids), and opium-derived drugs (benzylisoquinoline alkaloids).