刊物主题:Internal Medicine; Metabolic Diseases; Human Physiology;
出版者:Springer Berlin Heidelberg
ISSN:1432-0428
卷排序:60
文摘
Aims/hypothesisPancreatic beta cell dysfunction is a prerequisite for the development of type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic endocrine function and glucose homeostasis through alterations in gene regulation. Our aim was to investigate the role of HDAC7 in human and rat pancreatic islets and clonal INS-1 beta cells (INS-1 832/13).