Identification of positive selection in genes is greatly improved by using experimentally informed site-specific models

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• 作者：Jesse D. Bloom
• 关键词：Deep mutational scanning ; Phylogenetics ; Substitution model ; Diversifying selection ; dN/dS
• 刊名：Biology Direct
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：1687KB
• 刊物主题：Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1745-6150
• 卷排序：12

文摘

BackgroundSites of positive selection are identified by comparing observed evolutionary patterns to those expected under a null model for evolution in the absence of such selection. For protein-coding genes, the most common null model is that nonsynonymous and synonymous mutations fix at equal rates; this unrealistic model has limited power to detect many interesting forms of selection.