The effect of S1P receptor signaling pathway on the survival and drug resistance in multiple myeloma cells

详细信息    查看全文

• 作者：Di Fu ; Yingchun Li ; Jia Li ; Xiaoyan Shi…
• 关键词：Multiple myeloma (MM) ; Sphingosine ; 1 ; phosphate (S1P) ; Sphingosine ; 1 ; phosphate receptors (S1PRs) ; Cell survival ; Drug resistance
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：424
• 期：1-2
• 页码：185-193
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biochemistry, general; Medical Biochemistry; Oncology; Cardiology;
• 出版者：Springer US
• ISSN：1573-4919
• 卷排序：424

文摘

Multiple myeloma (MM) remains incurable by conventional chemotherapy. Sphingosine-1-phosphate (S1P) receptor-mediated signaling has been recently demonstrated to have critical roles in cell survival and drug resistance in a number of hematological malignancies. To dissect the roles of S1P receptor pathway in MM, we systematically examined cell viability and protein expression associated with cell survival and drug resistance in MM cell lines upon treatment with either pathway activator (S1P) or inhibitor (FTY720). Our results reveal that FTY720 inhibits cell proliferation by downregulating expression of target genes, while S1P has an opposite effect. Knocking down of S1P receptor S1P5R results in a reduction of cell survival-related gene expression; however, it does not have impacts on expression of drug resistance genes. These results suggest that S1P signaling plays a role in cell proliferation and drug resistance in MM, and targeting this pathway will provide a new therapeutic direction for MM management.