Two different dengue virus strains in the Japanese epidemics of 2014
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- 作者：Eri Nakayama ; Akira Kotaki ; Shigeru Tajima ; Miki Kawada ; Kuniharu Miura…
- 关键词：Dengue ; Envelope protein ; Dengue virus serotype 1 ; Aedes albopictus ; Japan
- 刊名：Virus Genes
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：52
- 期：5
- 页码：722-726
- 全文大小：375 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Medical Microbiology
Virology
Plant Sciences - 出版者：Springer Netherlands
- ISSN：1572-994X
- 卷排序：52
文摘
In late August 2014, dengue cases were reported in Japan, and a total of 162 cases were confirmed. In the present study, the envelope (E) gene sequences of 12 specimens from the dengue patients were determined. A dengue virus serotype 1 (DENV1) strain (D1/Hu/Shizuoka/NIID181/2014), which was clearly different from the first reported strain (D1/Hu/Saitama/NIID100/2014), was identified, although the other 11 specimens showed the same nucleotide sequences as D1/Hu/Saitama/NIID100/2014. The E gene sequences of two different strains were compared with those of nine DENV1 strains of imported cases in Japan in 2014. Phylogenetic analysis based on the E gene sequences showed that the D1/Hu/Saitama/NIID100/2014 strain was closely related to a strain isolated from an imported case from Singapore. Although no strain closely related to D1/Hu/Shizuoka/NIID181/2014 was found in these imported strains, the strain was closely related to isolates in Thailand and Taiwan in 2009. These data indicate that the dengue cases in Japan were caused by two different dengue virus strains that entered Japan through different means.