The roles of AXIN2 in tumorigenesis and epigenetic regulation

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• 作者：Shuang Li ; Chunpeng Wang ; Xiaodong Liu ; Shucheng Hua ; Xin Liu
• 关键词：AXIN2 ; Epigenetics ; Methylation ; MiRNA
• 刊名：Familial Cancer
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：14
• 期：2
• 页码：325-331
• 全文大小：552 KB
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• 作者单位：Shuang Li (1)
  Chunpeng Wang (2)
  Xiaodong Liu (3)
  Shucheng Hua (4)
  Xin Liu (1)
  
  1. Department of Epidemiology and Statistics, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, 130021, Jilin, China
  2. School of Mathematics and Statistics, Northeast Normal, Changchun, Jilin, China
  3. Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, China
  4. The First Hospital of Jilin University, Changchun, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Human Genetics
  Epidemiology
  
• 出版者：Springer Netherlands
• ISSN：1573-7292

文摘

AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on. The epigenetic regulation provides new insights for further exploring the pathogenesis of tumor. In this paper, the roles of AXIN2 in tumorigenesis, AXIN2 methylation, ubiquitination and siRNA/RNA regulation will be reviewed.