Level of plasmacytoid dendritic cells is increased in non-small cell lung carcinoma

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• 作者：Weiwei Shi (1)
  Xiaoyan Li (2)
  Jerry L. Porter (3)
  David H. Ostrodi (3)
  Bo Yang (1)
  Juan Li (1)
  Yishang Wang (1)
  Juan Zhang (1)
  Li Bai (1)
  Shunchang Jiao (1)
  
• 关键词：pDCs ; NSCLC ; Smoker patients
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：35
• 期：3
• 页码：2247-2252
• 全文大小：237 KB
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• 作者单位：Weiwei Shi (1)
  Xiaoyan Li (2)
  Jerry L. Porter (3)
  David H. Ostrodi (3)
  Bo Yang (1)
  Juan Li (1)
  Yishang Wang (1)
  Juan Zhang (1)
  Li Bai (1)
  Shunchang Jiao (1)
  
  1. Department of Oncology, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China
  2. Department of Lung Cancer, Hospital of Academy of Military Medical Sciences PLA, Beijing, 100071, China
  3. Faculty of Medicine, New York University, New York, NY, 10011, USA
  
• ISSN：1423-0380

文摘

In non-small cell lung carcinoma (NSCLC), the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within the tumor microenvironment. Plasmacytoid dendritic cells (pDCs) play critical roles in regulating the immune system. In this study, we investigated pDCs in the peripheral blood of NSCLC. CD4-?CD123-?BDCA2+ pDCs were tested from peripheral blood mononuclear cells in 52 NSCLC patients and 52 healthy controls by flow cytometry. Results revealed that proportion of pDCs was significantly increased in cases than in controls (0.52?±-.07?% versus 0.21?±-.02?%, p-lt;-.001), whereas myeloid dendritic cells (mDCs) did not present any obvious difference between patients and healthy donors (0.25?±-.04?% versus 0.18?±-.02?%, p--.120). We further studied pDCs in NSCLC patients with different clinical stages. Data showed that cases with higher stages (III/IV) had elevated level of pDCs than those with lower stages (I/II) (0.65?±-.09?% versus 0.25?±-.07?%, p--.006). In addition, the amount of pDCs was identified to be associated with squamous cell carcinoma, one of the major subtypes of NSCLC. Interestingly, we observed that smoking patients presented significantly elevated pDCs than those non-smokers (0.63?±-.09?% versus 0.22?±-.05?%, p--.008). These data suggested that pDCs may be closely involved in the pathogenesis of NSCLC and may predict the progression of the disease.