Transcatheter Closure of Perimembranous Ventricular Septal Defects with Left Ventricular to Right Atrial Shunt
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  • 作者:Gunter Kerst ; Axel Moysich ; Siew Yen Ho ; Christian Apitz…
  • 关键词:Congenital heart disease ; Perimembranous ventricular septal defect ; Gerbode defect ; Interventional cardiology
  • 刊名:Pediatric Cardiology
  • 出版年:2015
  • 出版时间:October 2015
  • 年:2015
  • 卷:36
  • 期:7
  • 页码:1386-1392
  • 全文大小:2,999 KB
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  • 作者单位:Gunter Kerst (1)
    Axel Moysich (1)
    Siew Yen Ho (2)
    Christian Apitz (1)
    Heiner Latus (1)
    Dietmar Schranz (1)

    1. Department of Pediatric Cardiology, Pediatric Heart Center Giessen, University Children’s Hospital, Feulgenstr. 10-12, 35392, Giessen, Germany
    2. Cardiac Morphology Unit, Royal Brompton Hospital, Imperial College London, London, UK
  • 刊物类别:Medicine
  • 刊物主题:Medicine & Public Health
    Cardiology
    Cardiac Surgery
    Vascular Surgery
  • 出版者:Springer New York
  • ISSN:1432-1971
文摘
During the development of so-called aneurysmal transformation of perimembranous ventricular septal defects (pmVSD), tricuspid valve (TV) morphology and function may be altered resulting in left ventricular (LV) to right atrial (RA) shunting. The feasibility and outcome of interventional closure of these pmVSD has not been investigated so far. Interventional closure of pmVSD associated with mild to moderate LV-to-RA shunt was performed in four patients (aged 6.5-2.5 years). pmVSD were closed under fluoroscopic guidance by establishing an arteriovenous wire loop via a femoral artery and advancing the delivery sheath from a femoral vein. Before device release (or withdrawal if necessary), residual shunting across the device and TV valve function was investigated by transthoracic echocardiography and LV angiography. pmVSD sizes of 4, 5.5, 8 and 8.5 mm were closed with a 4/4 and 6/6 Amplatzer duct occluder II and an 8- and 10-mm Amplatzer muscular VSD occluder device, respectively. There were no or only minor residual postinterventional LV-to-RA shunts. No atrioventricular blocks were observed during a mean follow-up of 12.5 months (range 6.5-7 months). Transthoracic echocardiography indicated that the elimination of the VSD jet pushing the antero-superior TV leaflet open is the key mechanism for LV-to-RA shunt reduction after transcatheter pmVSD closure. Interventional closure in pmVSD associated with mild to moderate indirect LV-to-RA shunting is feasible and results in significant reduction in or elimination of LV-to-RA shunting. Keywords Congenital heart disease Perimembranous ventricular septal defect Gerbode defect Interventional cardiology

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