Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines
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- 作者：Antje Jensch ; Caterina Thomaseth ; Nicole E. Radde
- 关键词：Quasi ; bistability ; MAPK signaling pathway ; Cellular decision making
- 刊名：BMC Systems Biology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：11
- 期：1
- 全文大小：2620KB
- 刊物主题：Bioinformatics; Systems Biology; Simulation and Modeling; Computational Biology/Bioinformatics; Physiological, Cellular and Medical Topics; Algorithms;
- 出版者：BioMed Central
- ISSN：1752-0509
- 卷排序：11
文摘
BackgroundPositive and negative feedback loops are ubiquitous motifs in biochemical signaling pathways. The mitogen-activated protein kinase (MAPK) pathway module is part of many distinct signaling networks and comprises several of these motifs, whose functioning depends on the cell line at hand and on the particular context.